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• W2315419647 abstract "Event Abstract Back to Event Mapping on chromosome 17 a novel major locus determining kidney cancer susceptibility in mice. José R. Jensen1, Antonella Galvan2, Maurizio Colecchia3, Wafa K. Cabrera1, Orlando G. Ribeiro1, Nancy Starobinas1, Andrea Borrego1, Marcelo De Franco1, Tommaso A. Dragani2 and Olga M. Ibañez1* 1 Instituto Butantan, Laboratory of Immunogenetics, Brazil 2 Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Predictive Medicine, Italy 3 Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Pathology, Italy Mouse lines derived by bidirectional phenotypic selection for inflammatory responsiveness differ in susceptibility to urethane-induced kidney carcinogenesis. High inflammation producing mice (AIRmax) are resistant whereas the low responder AIRmin are susceptible, showing 70% incidence of papillary kidney tumors (racemase positive) after sc treatment with 300 mg/kg bw urethane at 7 days of age. The difference is also observed in untreated 14 month-old mice, since AIRmax mice are unaffected and tumor incidence in AIRmin reaches 50%. Using a single nucleotide polymorphism (SNP) array for genome-wide linkage analysis, we mapped one quantitative trait locus (QTL) regulating kidney tumor incidence in an F2 (AIRmax x AIRmin) intercross population (n=693). This QTL mapped to chromosome 17 at 30 Mb (LOD score = 15.8, 13 Mb confidence interval), identified by SNP rs3693494 (P= 2.1-16, per allele odds ratio = 2.9, 95% CI: 2.2 - 3.7). Several candidate genes mapping in this locus have been implicated in inflammation-related kidney pathologies in humans, such as Pkd1, encoding polycystin-1, responsible for the polycystic kidney disease and Tsc2, a tumor suppressor gene encoding tuberin that participates in signal transduction pathways involved in cancer development. Genes relevant to innate and acquired immunity such as the major histocompatibility complex (H2) and C2 and C4 complement system components also map to this QTL. Functional effects of allelic variants could contribute to the differential susceptibility to inflammation and kidney cancer of AIRmax and AIRmin mice. Acknowledgements Finantial support: The State of São Paulo Research Foundation (FAPESP) and National Council of Research (CNPq), Brazil, and Associazione Italiana and Fondazione Italiana Ricerca Cancro (AIFIRC), Italy. Keywords: Inflammation, Kidney cancer, QTL, Urethane, Selected mouse lines Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Jensen JR, Galvan A, Colecchia M, Cabrera WK, Ribeiro OG, Starobinas N, Borrego A, De Franco M, Dragani TA and Ibañez OM (2013). Mapping on chromosome 17 a novel major locus determining kidney cancer susceptibility in mice.. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00177 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Olga M Ibañez, Instituto Butantan, Laboratory of Immunogenetics, São Paulo, Brazil, olgaibanez@butantan.gov.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers José R Jensen Antonella Galvan Maurizio Colecchia Wafa K Cabrera Orlando G Ribeiro Nancy Starobinas Andrea Borrego Marcelo De Franco Tommaso A Dragani Olga M Ibañez Google José R Jensen Antonella Galvan Maurizio Colecchia Wafa K Cabrera Orlando G Ribeiro Nancy Starobinas Andrea Borrego Marcelo De Franco Tommaso A Dragani Olga M Ibañez Google Scholar José R Jensen Antonella Galvan Maurizio Colecchia Wafa K Cabrera Orlando G Ribeiro Nancy Starobinas Andrea Borrego Marcelo De Franco Tommaso A Dragani Olga M Ibañez PubMed José R Jensen Antonella Galvan Maurizio Colecchia Wafa K Cabrera Orlando G Ribeiro Nancy Starobinas Andrea Borrego Marcelo De Franco Tommaso A Dragani Olga M Ibañez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2315419647 title "Mapping on chromosome 17 a novel major locus determining kidney cancer susceptibility in mice." @default.
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