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- W2315438431 abstract "Liver transplantation remains the only therapeutic option for most of acute and chronic end-stage liver diseases, but its use is limited by a severe shortage of donor organs for transplantation. In this contest the use of stem cells in cell therapy can be considered a promising therapeutical approach instead of liver transplantation.In particular, mesenchymal stem cells (MSCs) can be obtained from several adult tissues and from fetal-derived tissues, such as umbilical cord (UC), umbilical cord blood (UCB) and placenta, and they can be induced to differentiate into several cell types. Nevertheless, proliferative and differentiative potential of these cells has not yet been explained; particularly differentiative potential of fetal-derived tissue cells remains to be investigated. In this study, umbilical cord blood (UCB) and umbilical cord (UC) have been evaluated as potential sources of MSCs.For this purpose, the proliferative potential and plasticity of MSC isolated from UC and UCB to differentiate into adipogenic and osteogenic lineages in vitro were been investigated. After establishing of MSCs plasticity, the cells were differentiated in vitro towards hepatocyte-like cells, evaluating different biological supports for cell growth and differentiation. Finally, in view of clinical applications, the engraftment of these cells in a model of acute CCl4-induced liver injury has been verified.MSCs were capable of differentiating into hepatocyte-like cells as demonstrated by progressive up-regulation of mature hepatocyte markers. In particular the MSCs isolated from UC seem to acquire the features of mature hepatocyte as demonstrated by glycogen storage and albumin secretion. All finding suggested that these cells can grow and differentiate into functional hepatocyte-like cells without any biological support, whereas mature hepatocytes need a three-dimensional scaffold in order to maintain their viability and functional features. Finally the MSCs from human UC seem to contribute to liver regeneration by enhancing the reparative activity of hepatocytes that spontaneously occurs after injury, even if the mechanism of their action is not known.The establishment in vitro of the plasticity of UCB and UC not only towards mesodermal lineage cells but also towards endodermal lineage cells and the in vivo contribution of these cells to regenerate liver tissue, support their future application for cell therapy in acute and chronic liver disease. Moreover, due to availability, safety in the collection and lack of ethical issues, UCB and UC may become elective sources of multipotent MSC" @default.
- W2315438431 created "2016-06-24" @default.
- W2315438431 creator A5067130853 @default.
- W2315438431 date "2011-01-25" @default.
- W2315438431 modified "2023-09-26" @default.
- W2315438431 title "Studio delle capacità differenziative e della potenzialità terapeutica di cellule staminali mesenchimali umane isolate da cordone ombelicale e sangue cordonale nelle malattie epatiche acute." @default.
- W2315438431 hasPublicationYear "2011" @default.
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