Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315511885> ?p ?o ?g. }
- W2315511885 endingPage "9325" @default.
- W2315511885 startingPage "9316" @default.
- W2315511885 abstract "The chemical repair of radical-damaged DNA by glutathione in aqueous solution has been studied using density functional theory. Two main mechanisms were investigated: the single electron transfer (SET) and the hydrogen transfer (HT). Glutathione was found to repair radical damaged DNA by HT from the thiol group with rate constants that are close to the diffusion-limited regime, which means that the process is fast enough for repairing the damage before replication and therefore for preventing permanent DNA damage. The SET mechanism was found to be of minor importance for the activity of glutathione. In addition while SET can be essential for other compounds when repairing radical cation species, repairing the C′-centered guanosyl radicals via SET is not a viable mechanism, due to the very low electron affinity of these species. The importance of considering pH-related physiological conditions and using complex enough models, including the ribose moiety and the H bonding between base pairs, to study this kind of systems is discussed." @default.
- W2315511885 created "2016-06-24" @default.
- W2315511885 creator A5004634985 @default.
- W2315511885 creator A5053156610 @default.
- W2315511885 date "2012-07-30" @default.
- W2315511885 modified "2023-10-18" @default.
- W2315511885 title "On the Chemical Repair of DNA Radicals by Glutathione: Hydrogen vs Electron Transfer" @default.
- W2315511885 cites W1507082667 @default.
- W2315511885 cites W1523490929 @default.
- W2315511885 cites W1650754258 @default.
- W2315511885 cites W1964901949 @default.
- W2315511885 cites W1967577803 @default.
- W2315511885 cites W1973951571 @default.
- W2315511885 cites W1979907816 @default.
- W2315511885 cites W1981912201 @default.
- W2315511885 cites W1984759551 @default.
- W2315511885 cites W1986826567 @default.
- W2315511885 cites W1994591538 @default.
- W2315511885 cites W1994748126 @default.
- W2315511885 cites W1997464081 @default.
- W2315511885 cites W1998127752 @default.
- W2315511885 cites W1998162823 @default.
- W2315511885 cites W1998493527 @default.
- W2315511885 cites W2000774559 @default.
- W2315511885 cites W2001541958 @default.
- W2315511885 cites W2008901532 @default.
- W2315511885 cites W2009637194 @default.
- W2315511885 cites W2011215428 @default.
- W2315511885 cites W2015669071 @default.
- W2315511885 cites W2017994634 @default.
- W2315511885 cites W2022188604 @default.
- W2315511885 cites W2022734789 @default.
- W2315511885 cites W2023219008 @default.
- W2315511885 cites W2024394407 @default.
- W2315511885 cites W2025406523 @default.
- W2315511885 cites W2027383479 @default.
- W2315511885 cites W2027784487 @default.
- W2315511885 cites W2028029036 @default.
- W2315511885 cites W2030765885 @default.
- W2315511885 cites W2031904472 @default.
- W2315511885 cites W2033415076 @default.
- W2315511885 cites W2037017264 @default.
- W2315511885 cites W2038058650 @default.
- W2315511885 cites W2038260821 @default.
- W2315511885 cites W2044115606 @default.
- W2315511885 cites W2045450744 @default.
- W2315511885 cites W2047723546 @default.
- W2315511885 cites W2052517031 @default.
- W2315511885 cites W2055275145 @default.
- W2315511885 cites W2057980421 @default.
- W2315511885 cites W2061270600 @default.
- W2315511885 cites W2070474962 @default.
- W2315511885 cites W2073679464 @default.
- W2315511885 cites W2074251495 @default.
- W2315511885 cites W2077450957 @default.
- W2315511885 cites W2078712074 @default.
- W2315511885 cites W2078912605 @default.
- W2315511885 cites W2085569827 @default.
- W2315511885 cites W2088494225 @default.
- W2315511885 cites W2091237955 @default.
- W2315511885 cites W2092796597 @default.
- W2315511885 cites W2092889899 @default.
- W2315511885 cites W2104849963 @default.
- W2315511885 cites W2111412919 @default.
- W2315511885 cites W2115941430 @default.
- W2315511885 cites W2117626133 @default.
- W2315511885 cites W2124555115 @default.
- W2315511885 cites W2126849847 @default.
- W2315511885 cites W2128084403 @default.
- W2315511885 cites W2128372549 @default.
- W2315511885 cites W2129811654 @default.
- W2315511885 cites W2137213267 @default.
- W2315511885 cites W2156089353 @default.
- W2315511885 cites W2168163562 @default.
- W2315511885 cites W2171445884 @default.
- W2315511885 cites W2176353450 @default.
- W2315511885 cites W2213178447 @default.
- W2315511885 cites W2505074369 @default.
- W2315511885 cites W2785360107 @default.
- W2315511885 cites W3021518424 @default.
- W2315511885 cites W4249841422 @default.
- W2315511885 doi "https://doi.org/10.1021/jp303116n" @default.
- W2315511885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22799525" @default.
- W2315511885 hasPublicationYear "2012" @default.
- W2315511885 type Work @default.
- W2315511885 sameAs 2315511885 @default.
- W2315511885 citedByCount "81" @default.
- W2315511885 countsByYear W23155118852013 @default.
- W2315511885 countsByYear W23155118852014 @default.
- W2315511885 countsByYear W23155118852015 @default.
- W2315511885 countsByYear W23155118852016 @default.
- W2315511885 countsByYear W23155118852017 @default.
- W2315511885 countsByYear W23155118852018 @default.
- W2315511885 countsByYear W23155118852019 @default.
- W2315511885 countsByYear W23155118852020 @default.
- W2315511885 countsByYear W23155118852021 @default.
- W2315511885 countsByYear W23155118852022 @default.
- W2315511885 countsByYear W23155118852023 @default.