Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315562282> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2315562282 endingPage "e237" @default.
- W2315562282 startingPage "e237" @default.
- W2315562282 abstract "Background: Endothelin-1 (ET-1) causes sustained and long-lasting vasoconstrictions by tight binding to ETA-receptors. ETA-receptor antagonists can prevent binding of ET-1 to ETA-receptors and reduce the activity of ET-1/ETA-complexes only to some extent. Therefore we tested the hypothesis that vasodilators could be superior anti-endothelinergic drugs in the vasculature than ETA-receptor antagonists. Materials and methods: We used wire myography to investigate ETA-receptor mediated arterial contractions of rat mesenteric resistance arteries, in a setting minimizing the effects of endothelium and sensory-motor nerves and analysed effects of vasodilator pathways on initiation, maintenance and persistence of 40 mM K+-induced contractions and on ET-1-induced contractions (0.25 – 16 nM). Results: Felodipine (1 nM), a calcium channel blocker, hydroxyfasudil (10 μM), a RhoK inhibitor, and Bay412272 (10 μM) and Bay602770 (1 μM), a soluble guanylate cyclase (sGC) stimulator and activator, respectively, each caused significant reduction of K+-induced contractions. These vasodilators reduced sensitivity to ET-1 only moderately (∼3-fold). RhoK inhibition reversibly relaxed persistent ET-1-precontracted arteries, but not the maintained contractions in presence of ET-1. sGC stimulation or activation moderately and strongly relaxed maintained and persistent ET-1-precontracted arteries, respectively, and this was only partly reversible. Blocking calcium channels strongly relaxed both maintained and persistent ET-1-precontracted arteries irreversibly. Conclusions: These findings indicate that different mechanisms are involved in the initiation, maintenance and persistence of arterial contractile responses to ET-1. Certain functional antagonists may be better suited to inhibit ET-1-initiated effects than ETA-receptor antagonists. This study was performed within the framework of TI Pharma project T2-301." @default.
- W2315562282 created "2016-06-24" @default.
- W2315562282 creator A5036839956 @default.
- W2315562282 creator A5049359215 @default.
- W2315562282 creator A5068995309 @default.
- W2315562282 date "2012-09-01" @default.
- W2315562282 modified "2023-09-26" @default.
- W2315562282 title "815 DISTINCT MECHANISMS INVOLVED IN INITIATION AND PERSISTENCE OF ENDOTHELIN-1-INDUCED VASOCONSTRICTIONS" @default.
- W2315562282 doi "https://doi.org/10.1097/01.hjh.0000420844.32332.65" @default.
- W2315562282 hasPublicationYear "2012" @default.
- W2315562282 type Work @default.
- W2315562282 sameAs 2315562282 @default.
- W2315562282 citedByCount "0" @default.
- W2315562282 crossrefType "journal-article" @default.
- W2315562282 hasAuthorship W2315562282A5036839956 @default.
- W2315562282 hasAuthorship W2315562282A5049359215 @default.
- W2315562282 hasAuthorship W2315562282A5068995309 @default.
- W2315562282 hasBestOaLocation W23155622821 @default.
- W2315562282 hasConcept C120770815 @default.
- W2315562282 hasConcept C126322002 @default.
- W2315562282 hasConcept C134018914 @default.
- W2315562282 hasConcept C144980905 @default.
- W2315562282 hasConcept C149601957 @default.
- W2315562282 hasConcept C170493617 @default.
- W2315562282 hasConcept C24998067 @default.
- W2315562282 hasConcept C2776820930 @default.
- W2315562282 hasConcept C2779961880 @default.
- W2315562282 hasConcept C2780771799 @default.
- W2315562282 hasConcept C2909649922 @default.
- W2315562282 hasConcept C71924100 @default.
- W2315562282 hasConcept C98274493 @default.
- W2315562282 hasConceptScore W2315562282C120770815 @default.
- W2315562282 hasConceptScore W2315562282C126322002 @default.
- W2315562282 hasConceptScore W2315562282C134018914 @default.
- W2315562282 hasConceptScore W2315562282C144980905 @default.
- W2315562282 hasConceptScore W2315562282C149601957 @default.
- W2315562282 hasConceptScore W2315562282C170493617 @default.
- W2315562282 hasConceptScore W2315562282C24998067 @default.
- W2315562282 hasConceptScore W2315562282C2776820930 @default.
- W2315562282 hasConceptScore W2315562282C2779961880 @default.
- W2315562282 hasConceptScore W2315562282C2780771799 @default.
- W2315562282 hasConceptScore W2315562282C2909649922 @default.
- W2315562282 hasConceptScore W2315562282C71924100 @default.
- W2315562282 hasConceptScore W2315562282C98274493 @default.
- W2315562282 hasIssue "Supplement 1" @default.
- W2315562282 hasLocation W23155622821 @default.
- W2315562282 hasLocation W23155622822 @default.
- W2315562282 hasOpenAccess W2315562282 @default.
- W2315562282 hasPrimaryLocation W23155622821 @default.
- W2315562282 hasRelatedWork W115432672 @default.
- W2315562282 hasRelatedWork W1983289760 @default.
- W2315562282 hasRelatedWork W1993069514 @default.
- W2315562282 hasRelatedWork W2013859159 @default.
- W2315562282 hasRelatedWork W2017344644 @default.
- W2315562282 hasRelatedWork W2051289134 @default.
- W2315562282 hasRelatedWork W2054381541 @default.
- W2315562282 hasRelatedWork W2059474066 @default.
- W2315562282 hasRelatedWork W2160355439 @default.
- W2315562282 hasRelatedWork W2413284495 @default.
- W2315562282 hasVolume "30" @default.
- W2315562282 isParatext "false" @default.
- W2315562282 isRetracted "false" @default.
- W2315562282 magId "2315562282" @default.
- W2315562282 workType "article" @default.