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- W2315569162 abstract "細胞増殖因子であるepidermal growth factor (EGF) の胃切開縫合創の治癒に対する影響について実験的に検討した.ラットを対照群, 胃切開後48時間までEGFを投与した群に加えて, 内因性EGFを低下させる目的で両側顎下腺を摘出したsubmandibular glands removal (SMR) 群とSMRラットにEGFを投与したSMR+EGF群の4群に分けた.なおEGF (20μg/kg) を投与した群では胃手術前1時間, 術後24, 48時間に静注した, 胃手術後3, 7日目に胃切開創の組織血流量, 新生毛細血管の構築および量, 抗張力および組織化学的観察による局所コラーゲン組織化学的所見から創傷治癒を検討した.各項目について, EGF群と対照群の間には有意差はなかったが, SMR群では抗張力, 組織血流量毛細血管新生の低下が認められた.SMR+EGF群では, 投与後, 各項目は対照群と同程度まで回復した.EGFは毛細血管新生と組織血流維持に必要であり, 胃切開創の創傷治癒に重要な役割を持つと考えられた." @default.
- W2315569162 created "2016-06-24" @default.
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- W2315569162 date "1993-01-01" @default.
- W2315569162 modified "2023-10-18" @default.
- W2315569162 title "The Effect of Epidermal Growth Factor on the Wound Healing after Gastrotomy." @default.
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- W2315569162 doi "https://doi.org/10.5833/jjgs.26.8" @default.
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