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- W2315573158 abstract "The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationalizes the role of NMI is proposed, and a gram-scale procedure for the synthesis and resolution of 10 is also described." @default.
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- W2315573158 date "2014-07-24" @default.
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- W2315573158 title "<i>N</i>-Methylimidazole Promotes the Reaction of Homophthalic Anhydride with Imines" @default.
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- W2315573158 doi "https://doi.org/10.1021/jo501316m" @default.
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