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- W2315657671 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILBackground:Current studies have demonstrated that neoadjuvant chemotherapy (NAC) improves survival outcomes and increases the chance for breast conservation when applied preoperatively. However, no reliable maker to predict chemosensitivity of NAC is not available. CD133 has been considered as a cancer stem cells (CSCs) marker in many kinds of tumors such as breast cancer, colorectal cancer and brain cancer. The aim of this study was to evaluate the value of CD133 as a surrogate maker to predict chemosensitivity of NAC for breast cancer. Experimental Design: A total of 102 patients with breast cancer of stage II and III, as evaluated by core needle biopsy and ultrasonography, was treated with NAC. Expressions of CD133, estrogen receptor, progesterone receptor, and HER2 were assessed by immunohistochemistry. Results: The clinical complete response (CR) rate of all patients was 18% (18/102), partial response (PR) was 61% (62/102), no change (NC) was 20% (20/102), and progressive disease (PD) was 2% (2 /102). The response rate (RR) was 78% (80/102). The pathological complete response rate (pCR) was 29%. The pCR rate and pathological response of CD133-positive cases was significantly lower than that of CD133-negative cases. The recurrence rate of CD133-positive cases was significantly higher than that of CD133-negative cases. CD133 expression showed a poor disease free survival and overall survival time. A multivariate logistic regression analysis showed that CD133 expression was an independent prognostic factor in breast cancers treated with NAC. Conclusion: CD133 is a useful surrogate maker to predict chemosensitivity of NAC chemotherapy for breast cancer.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 707. doi:1538-7445.AM2012-707" @default.
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- W2315657671 date "2012-04-15" @default.
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- W2315657671 title "Abstract 707: CD133 is a useful surrogate marker to predict chemosensitivity of neoadjuvant chemotherapy for breast cancer" @default.
- W2315657671 doi "https://doi.org/10.1158/1538-7445.am2012-707" @default.
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