Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315662615> ?p ?o ?g. }
- W2315662615 endingPage "1046" @default.
- W2315662615 startingPage "1037" @default.
- W2315662615 abstract "Abstract IFN-α production by pDCs regulates host protection against viruses and is implicated in autoimmune pathology. Human pDCs express high levels of IL-18R, but little is known of its role in pDC function. We report that IL-18R signaling negatively regulates IFN-α production through activation-induced splicing of IL-18Rα in human pDCs. Our data reveal two distinct isoforms of IL-18Rα in human pDCs: the known, full-length receptor (IL-18Rα1) and a novel, truncated variant (IL-18Rα2), which functions as a molecular decoy that competitively inhibits the canonical IL-18Rα1/IL-18Rβ signaling pathway. Whereas NK cells and pDCs both express IL-18Rα1, pDCs express significantly higher levels of IL-18Rα2, resulting in differential responses of these populations to IL-18. Flu exposure increases IL-18Rα1 expression in pDCs, and the blocking of IL-18R enhances pDC production of IFN-α and IP-10; thus, pDCs use activation-induced splicing to regulate IFN-α production in response to flu. These data demonstrate that IL-18R modulates IFN-α release by human pDCs and suggest that IL-18R signaling may represent a promising therapeutic target." @default.
- W2315662615 created "2016-06-24" @default.
- W2315662615 creator A5010255195 @default.
- W2315662615 creator A5018125080 @default.
- W2315662615 creator A5032272395 @default.
- W2315662615 creator A5045619685 @default.
- W2315662615 creator A5050267398 @default.
- W2315662615 creator A5057282202 @default.
- W2315662615 creator A5079113367 @default.
- W2315662615 creator A5086810467 @default.
- W2315662615 date "2014-08-28" @default.
- W2315662615 modified "2023-09-26" @default.
- W2315662615 title "Human plasmacytoid dendritic cells regulate IFN-α production through activation-induced splicing of IL-18Rα" @default.
- W2315662615 cites W1517310071 @default.
- W2315662615 cites W1575120320 @default.
- W2315662615 cites W1706538155 @default.
- W2315662615 cites W1906667724 @default.
- W2315662615 cites W1968649377 @default.
- W2315662615 cites W1976026635 @default.
- W2315662615 cites W1986279897 @default.
- W2315662615 cites W1997573685 @default.
- W2315662615 cites W2003210438 @default.
- W2315662615 cites W2006772331 @default.
- W2315662615 cites W2015627239 @default.
- W2315662615 cites W2018078765 @default.
- W2315662615 cites W2020000056 @default.
- W2315662615 cites W2020811214 @default.
- W2315662615 cites W2029029038 @default.
- W2315662615 cites W2029629696 @default.
- W2315662615 cites W2034984303 @default.
- W2315662615 cites W2044162906 @default.
- W2315662615 cites W2046841302 @default.
- W2315662615 cites W2048143404 @default.
- W2315662615 cites W2049204810 @default.
- W2315662615 cites W2060438123 @default.
- W2315662615 cites W2065528190 @default.
- W2315662615 cites W2069273393 @default.
- W2315662615 cites W2074575319 @default.
- W2315662615 cites W2079110418 @default.
- W2315662615 cites W2100412095 @default.
- W2315662615 cites W2104254580 @default.
- W2315662615 cites W2106273198 @default.
- W2315662615 cites W2111220263 @default.
- W2315662615 cites W2116265508 @default.
- W2315662615 cites W2119931715 @default.
- W2315662615 cites W2133779525 @default.
- W2315662615 cites W2134062610 @default.
- W2315662615 cites W2150452566 @default.
- W2315662615 cites W2152507275 @default.
- W2315662615 cites W2160628268 @default.
- W2315662615 cites W2164838962 @default.
- W2315662615 cites W2168888135 @default.
- W2315662615 cites W2169127097 @default.
- W2315662615 cites W2171831396 @default.
- W2315662615 cites W2331166595 @default.
- W2315662615 cites W4236307695 @default.
- W2315662615 doi "https://doi.org/10.1189/jlb.2a0813-465rr" @default.
- W2315662615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25170117" @default.
- W2315662615 hasPublicationYear "2014" @default.
- W2315662615 type Work @default.
- W2315662615 sameAs 2315662615 @default.
- W2315662615 citedByCount "4" @default.
- W2315662615 countsByYear W23156626152016 @default.
- W2315662615 countsByYear W23156626152017 @default.
- W2315662615 countsByYear W23156626152020 @default.
- W2315662615 crossrefType "journal-article" @default.
- W2315662615 hasAuthorship W2315662615A5010255195 @default.
- W2315662615 hasAuthorship W2315662615A5018125080 @default.
- W2315662615 hasAuthorship W2315662615A5032272395 @default.
- W2315662615 hasAuthorship W2315662615A5045619685 @default.
- W2315662615 hasAuthorship W2315662615A5050267398 @default.
- W2315662615 hasAuthorship W2315662615A5057282202 @default.
- W2315662615 hasAuthorship W2315662615A5079113367 @default.
- W2315662615 hasAuthorship W2315662615A5086810467 @default.
- W2315662615 hasBestOaLocation W23156626151 @default.
- W2315662615 hasConcept C104317684 @default.
- W2315662615 hasConcept C14036430 @default.
- W2315662615 hasConcept C170493617 @default.
- W2315662615 hasConcept C2779179475 @default.
- W2315662615 hasConcept C54458228 @default.
- W2315662615 hasConcept C55493867 @default.
- W2315662615 hasConcept C62478195 @default.
- W2315662615 hasConcept C67705224 @default.
- W2315662615 hasConcept C86803240 @default.
- W2315662615 hasConcept C95444343 @default.
- W2315662615 hasConceptScore W2315662615C104317684 @default.
- W2315662615 hasConceptScore W2315662615C14036430 @default.
- W2315662615 hasConceptScore W2315662615C170493617 @default.
- W2315662615 hasConceptScore W2315662615C2779179475 @default.
- W2315662615 hasConceptScore W2315662615C54458228 @default.
- W2315662615 hasConceptScore W2315662615C55493867 @default.
- W2315662615 hasConceptScore W2315662615C62478195 @default.
- W2315662615 hasConceptScore W2315662615C67705224 @default.
- W2315662615 hasConceptScore W2315662615C86803240 @default.
- W2315662615 hasConceptScore W2315662615C95444343 @default.
- W2315662615 hasFunder F4320320696 @default.
- W2315662615 hasIssue "6" @default.
- W2315662615 hasLocation W23156626151 @default.