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• W2315692871 abstract "Aristolochic acid I (AA-I), naturally occurring in Aristolochia plants, is a potent nephrotoxin and carcinogen. Here we report that AA-I suffers hydrogenolysis with loss of the nitro group by reaction with cysteine or glutathione to give aristolic acid. Since the reaction can proceed in aqueous solutions at pH 7.0 and 37 °C, it is inferred that it may also occur in biological systems and contribute to the nephrotoxic effects induced by AA-I." @default.
• W2315692871 created "2016-06-24" @default.
• W2315692871 creator A5018437749 @default.
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• W2315692871 date "2013-04-24" @default.
• W2315692871 modified "2023-09-25" @default.
• W2315692871 title "Conversion of Aristolochic Acid I into Aristolic Acid by Reaction with Cysteine and Glutathione: Biological Implications" @default.
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• W2315692871 doi "https://doi.org/10.1021/np300822b" @default.
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• W2315692871 hasPublicationYear "2013" @default.
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