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- W2315693428 endingPage "484" @default.
- W2315693428 startingPage "477" @default.
- W2315693428 abstract "Internucleosomal DNA fragmentation is generally perceived as one of the characteristic features of apoptosis, most of which are driven by caspase activation dependent upon ATP. On the other hand, ATP depletion has been reported to induce apoptosis accompanying DNA fragmentation. To address this apparent paradox, we analyzed the DNA-fragmenting activity generated in ATP-depleted cells. In HL-60 promyelocytic leukemia cells cultured in glucose-free medium with oligomycin, internucleosomal DNA fragmentation occurred as an early event. The DNA fragmentation was blocked by serine protease inhibitors but not by caspase inhibitors. Consistently, ICAD/DFF45 could not inhibit the DNA-fragmenting activity of the ATP-depleted cytosol in a cell-free system. When ATP was supplied to the cell-free assay, 80% of the DNA-fragmenting activity was lost. The reduced activity was then restored by proteasome inhibitors, suggesting a role of proteasome to protect from a cellular insult derived from ATP-depletion. Cell Death and Differentiation (2000) 7, 477–484" @default.
- W2315693428 created "2016-06-24" @default.
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- W2315693428 creator A5060849895 @default.
- W2315693428 date "2000-04-28" @default.
- W2315693428 modified "2023-10-11" @default.
- W2315693428 title "Properties of DNA fragmentation activity generated by ATP depletion" @default.
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- W2315693428 doi "https://doi.org/10.1038/sj.cdd.4400677" @default.
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