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- W2315702430 abstract "Three kinds of eptazocine hydrobromide(EP) suppositories were prepared by fusion method : oleaginous-base conventional type (C-type), oleaginous hollow type (H-type) and polyethylene glycol type (PEG-type). Release tests in vitro were carried out according to Muranishi's method, and rectal absorptions of EP contained in three kinds of suppositories were investigated using four rabbits. The release rate of EP from H-type was larger than those from the other two kinds of suppositories in early phase, whereas the cumulative release percentage from PEG-type showed the highest value at 300 min. In the rectal absorption studies, the maximum plasma concentration (Cmax) of PEG-type was about a fourth of those of the other suppositories. And the other two kinds of oleaginous base suppositories gave significantly shorter Tmax (the time to reach Cmax) than that of PEG-type. The mean bioavailability of C-type, H-type and PEG-type was 61.1%, 36.6% and 18.2% respectively. These results suggest that C-type and H-type may be put to good use as a rectal dosage form of EP." @default.
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- W2315702430 date "1991-01-01" @default.
- W2315702430 modified "2023-10-04" @default.
- W2315702430 title "Studies on the optimum dosage form for rectal administration of eptazocine." @default.
- W2315702430 doi "https://doi.org/10.2745/dds.6.443" @default.
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