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- W2315705883 abstract "Purpose: In the TRITON-TIMI 38 study prasugrel reduced the primary endpoint (PEP) - a composite of cardiovascular death, nonfatal myocardial infarction (MI) or nonfatal stroke - as compared to clopidogrel in patients (pts) with acute coronary syndromes (ACS). While separate outcomes for pts with ST-elevation (STE) MI have been published, data for unstable angina (UA) and NSTEMI pts are only available for the PEP and for these 2 groups pooled. Methods: This analysis presents data of PEP, all-cause death, non-CABG TIMI major bleeding and net clinical benefit (NCB, which includes major bleeding) for the entire cohort of 10.074 NSTE-ACS pts, as well as for 2528 UA pts and 7541 NSTEMI pts separately. Additional analyses were performed excluding pts not recommended by the prasugrel label in Europe, e.g. with previous TIA/stroke, age of 75 and over, weight less than 60kg (core cohort), and with the analyses truncated at 360 days. Results: There was a consistent and significant reduction in the occurrence of PEP with prasugrel compared with clopidogrel in the entire NSTE-ACS cohort as well as in the UA and NSTEMI groups (p interaction 0.390). While NCB was improved with prasugrel (HR 0.89, p 0.043), non-CABG TIMI major bleeding was increased (HR 1.40, p 0.022), and these findings were consistent for the 2 groups analyzed here (p interaction 0.724 and 0.839). Limiting the analysis to pts according to the prasugrel label, this drug consistently showed superiority over clopidogrel with regards to PEP and NCB (p interaction 0.932 and 0.940), without significant difference in non-CABG TIMI major bleeding (p interaction 0.522). Conclusion: Main clinical outcomes in separate UA or NSTEMI patient groups from the TRITON-TIMI 38 study are consistent with data for the entire NSTE-ACS cohort of the study." @default.
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- W2315705883 date "2013-08-02" @default.
- W2315705883 modified "2023-09-23" @default.
- W2315705883 title "Clinical outcomes for prasugrel versus clopidogrel are consistent among patients from TRITON-TIMI 38 with unstable angina or non-ST-elevation myocardial infarction" @default.
- W2315705883 doi "https://doi.org/10.1093/eurheartj/eht310.p4847" @default.
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