FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315722034> ?p ?o ?g. }

• W2315722034 endingPage "1801" @default.
• W2315722034 startingPage "1781" @default.
• W2315722034 abstract "Aims: Develop an anti-tuberculosis (TB) Fixed Dose Combination (FDC) tablet containing an immediate release layer (IRL) composed of both rifampicin (RIF) and pyrazinamide (PYR) and a retarded release layer (RRL) comprised of isoniazid (INH) which would allow segregated delivery of RIF and INH. Study Design: Trials were conducted on the pre-formulations and formulations to assess the compatibility of excipients and obtain a modified release profile, for an IRL consisting of both RIF and PYR and a RRL containing INH. Place and Duration of Study: This study was performed at the Laboratory of Pharmaceutical Industrial Technology, Drug and Pharmaceutical Department, Faculty of Original Research Article British Journal of Pharmaceutical Research, 4(14): 1781-1801, 2014 1782 Pharmacy, between March 2008 and April 2010. Methodology: Preformulation studies were performed on RIF and PYR, alone and in combination with excipients. The pharmacopeic attributes of the distinct layers and the FDC tablets were evaluated for hardness, friability and disintegration time. The FDC bilayer tablets were analyzed for their drug content and cumulative dissolution of the drug. Results: Fourier transform infrared, x-ray diffraction and differential scanning calorimetry results revealed the presence of amorphous and crystalline RIF forms and no potentially relevant incompatibilities were identified in the kneaded system containing RIF, PYR and excipients. In vitro drug release from the FDC tablets revealed that the intragranular addition of croscarmellose sodium into the IRL rendered a cumulative dissolution of RIF and PYR within the limits of simulated gastric fluid. And, for RRL, the most effective retardant matrix excipient was found to be hydroxypropyl methylcellulose. Conclusion: Segregated delivery of RIF and INH from bilayer tablets is an option for the development of immediate release FDC tablets and the retarded release of INH, this strategy proved suitable for preventing contact of these two drugs under acidic conditions. This finding suggested that RIF had a high in vivo bioavailability which qualifies this FDC for future bioavailability studies." @default.
• W2315722034 created "2016-06-24" @default.
• W2315722034 creator A5078435506 @default.
• W2315722034 date "2014-01-10" @default.
• W2315722034 modified "2023-10-18" @default.
• W2315722034 title "Segregated Delivery of Rifampicin and Isoniazid from Fixed Dose Combination Bilayer Tablets for the Treatment of Tuberculosis" @default.
• W2315722034 cites W1968683848 @default.
• W2315722034 cites W1977196372 @default.
• W2315722034 cites W1977396501 @default.
• W2315722034 cites W1977933400 @default.
• W2315722034 cites W1979712504 @default.
• W2315722034 cites W1979745527 @default.
• W2315722034 cites W1984699742 @default.
• W2315722034 cites W1995623968 @default.
• W2315722034 cites W1998224020 @default.
• W2315722034 cites W2014070105 @default.
• W2315722034 cites W2019544450 @default.
• W2315722034 cites W2019582371 @default.
• W2315722034 cites W2029544602 @default.
• W2315722034 cites W2039369893 @default.
• W2315722034 cites W2044530764 @default.
• W2315722034 cites W2046498709 @default.
• W2315722034 cites W2047281641 @default.
• W2315722034 cites W2048874605 @default.
• W2315722034 cites W2054910784 @default.
• W2315722034 cites W2056570578 @default.
• W2315722034 cites W2064899182 @default.
• W2315722034 cites W2068053093 @default.
• W2315722034 cites W2070741475 @default.
• W2315722034 cites W2071558726 @default.
• W2315722034 cites W2080023951 @default.
• W2315722034 cites W2083241107 @default.
• W2315722034 cites W2083247522 @default.
• W2315722034 cites W2083339566 @default.
• W2315722034 cites W2085244189 @default.
• W2315722034 cites W2094625675 @default.
• W2315722034 cites W2100882336 @default.
• W2315722034 cites W2106644650 @default.
• W2315722034 cites W2107181190 @default.
• W2315722034 cites W2113265821 @default.
• W2315722034 cites W2127257878 @default.
• W2315722034 cites W2132680062 @default.
• W2315722034 cites W2134338177 @default.
• W2315722034 cites W2144968903 @default.
• W2315722034 cites W2145318438 @default.
• W2315722034 cites W2414873657 @default.
• W2315722034 cites W31832189 @default.
• W2315722034 cites W65039510 @default.
• W2315722034 cites W366803544 @default.
• W2315722034 doi "https://doi.org/10.9734/bjpr/2014/11525" @default.
• W2315722034 hasPublicationYear "2014" @default.
• W2315722034 type Work @default.
• W2315722034 sameAs 2315722034 @default.
• W2315722034 citedByCount "5" @default.
• W2315722034 countsByYear W23157220342017 @default.
• W2315722034 countsByYear W23157220342021 @default.
• W2315722034 countsByYear W23157220342022 @default.
• W2315722034 crossrefType "journal-article" @default.
• W2315722034 hasAuthorship W2315722034A5078435506 @default.
• W2315722034 hasConcept C142724271 @default.
• W2315722034 hasConcept C185592680 @default.
• W2315722034 hasConcept C192157962 @default.
• W2315722034 hasConcept C2776623344 @default.
• W2315722034 hasConcept C2776967927 @default.
• W2315722034 hasConcept C2778607973 @default.
• W2315722034 hasConcept C2781069245 @default.
• W2315722034 hasConcept C41625074 @default.
• W2315722034 hasConcept C55493867 @default.
• W2315722034 hasConcept C71924100 @default.
• W2315722034 hasConcept C98274493 @default.
• W2315722034 hasConceptScore W2315722034C142724271 @default.
• W2315722034 hasConceptScore W2315722034C185592680 @default.
• W2315722034 hasConceptScore W2315722034C192157962 @default.
• W2315722034 hasConceptScore W2315722034C2776623344 @default.
• W2315722034 hasConceptScore W2315722034C2776967927 @default.
• W2315722034 hasConceptScore W2315722034C2778607973 @default.
• W2315722034 hasConceptScore W2315722034C2781069245 @default.
• W2315722034 hasConceptScore W2315722034C41625074 @default.
• W2315722034 hasConceptScore W2315722034C55493867 @default.
• W2315722034 hasConceptScore W2315722034C71924100 @default.
• W2315722034 hasConceptScore W2315722034C98274493 @default.
• W2315722034 hasIssue "14" @default.
• W2315722034 hasLocation W23157220341 @default.
• W2315722034 hasOpenAccess W2315722034 @default.
• W2315722034 hasPrimaryLocation W23157220341 @default.
• W2315722034 hasRelatedWork W1967225140 @default.
• W2315722034 hasRelatedWork W1985603351 @default.
• W2315722034 hasRelatedWork W2012320745 @default.
• W2315722034 hasRelatedWork W2083241107 @default.
• W2315722034 hasRelatedWork W2341807218 @default.
• W2315722034 hasRelatedWork W2351859577 @default.
• W2315722034 hasRelatedWork W2426670041 @default.
• W2315722034 hasRelatedWork W2782995983 @default.
• W2315722034 hasRelatedWork W2938138842 @default.
• W2315722034 hasRelatedWork W68829940 @default.
• W2315722034 hasVolume "4" @default.
• W2315722034 isParatext "false" @default.
• W2315722034 isRetracted "false" @default.

• next