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- W2315743693 abstract "In a recent correspondence to Radiation Research, Slijepcevic and Bryant (1) suggested that the addition of new telomeric repeat sequences to the ends of broken chromosomes, termed chromosome healing, is a rare and selective event and therefore is likely to be of little importance in the response of mammalian cells to double-strand breaks. Although citing observations from a number of different organisms, this letter fails to point out results obtained from studies in humans. Terminal deletions have been shown to be associated with a wide variety of birth defects in humans (2). Only a handful of terminal deletions have been analyzed at the sequence level, but in all cases these have resulted from telomeric repeat sequences being added on directly to the ends of the broken chromosomes, i.e. chromosome healing. These examples include six cases of thalassemia resulting from terminal deletions on the short arm of chromosome 16 (3) and one case of mild me tal retardation resulting from a terminal deletion on the long arm of chromosome 22 (4). Sequence analysis of chromosome healing in somatic human cells has not been reported, but in one instance plasmid sequences transfected into an immortal human cell line were shown to pick up telomeric repeat sequences Response to the Letter of Dr. Sherman and Correction of Error in Radiat. Res. 148, 348-358 (1997)" @default.
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- W2315743693 date "1998-03-01" @default.
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- W2315743693 title "Response to the Letter of Dr. Sherman and Correction of Error in Radiat. Res. 148, 348-358 (1997)" @default.
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- W2315743693 doi "https://doi.org/10.2307/3579967" @default.
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