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- W2315845902 abstract "1,2-Dihydro-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide was synthesized by condensation of the silylated pyrazine base with the blocked chloro sugar, followed by removal of the protecting groups. The compound inhibited the growth of leukemia L1210 cells in vitro by 50% at 2 x 10-7 M. At 400 mg/kg/day x 6 it increased the life-span of leukemia L1210 bearing mice by approximately 55%, without apparent toxicity to the host." @default.
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- W2315845902 date "1977-03-01" @default.
- W2315845902 modified "2023-09-27" @default.
- W2315845902 title "Synthesis and antitumor activity of 1,2-dihydro-1-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide, a structural analog of thymidine" @default.
- W2315845902 doi "https://doi.org/10.1021/jm00213a029" @default.
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