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- W2315880537 abstract "The propositus was a 39-yr.-old woman who gave a history of excessive bleeding following surgery, but apart from frequent epistaxes as a child, no spontaneous haemorrhage. Her daughter, who also has a low level of Factor XI, had undergone an uneventful appendectomy and normal pregnancy. Laboratory studies revealed a normal bleeding time, a prolonged whole blood clotting time and a prolonged partial thromboplastin time with kaolin. The thromboplastin generation test was abnormal using the patient's serum or absorbed plasma while the patient's plasma corrected the defect in the plasma from a patient with Factor XII deficiency. The diagnosis of Factor XI deficiency was confirmed by the failure of her plasma to correct plasmas artificially depleted of Factor XI and from a patient with known Factor XI deficiency (Rosenthal's original patient). The therapeutic management of the patient undergoing hysterectomy was described. The postoperative course was punctuated by a severe hacmorrhage when the level of Factor XI dropped to below 20%. She obtained the calculated rise in Factor XI following transfusion with fresh frozen plasma and the half life of Factor XI was found to be about 40 hr. The propositus was a 39-yr.-old woman who gave a history of excessive bleeding following surgery, but apart from frequent epistaxes as a child, no spontaneous haemorrhage. Her daughter, who also has a low level of Factor XI, had undergone an uneventful appendectomy and normal pregnancy. Laboratory studies revealed a normal bleeding time, a prolonged whole blood clotting time and a prolonged partial thromboplastin time with kaolin. The thromboplastin generation test was abnormal using the patient's serum or absorbed plasma while the patient's plasma corrected the defect in the plasma from a patient with Factor XII deficiency. The diagnosis of Factor XI deficiency was confirmed by the failure of her plasma to correct plasmas artificially depleted of Factor XI and from a patient with known Factor XI deficiency (Rosenthal's original patient). The therapeutic management of the patient undergoing hysterectomy was described. The postoperative course was punctuated by a severe hacmorrhage when the level of Factor XI dropped to below 20%. She obtained the calculated rise in Factor XI following transfusion with fresh frozen plasma and the half life of Factor XI was found to be about 40 hr." @default.
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- W2315880537 date "1972-01-01" @default.
- W2315880537 modified "2023-09-25" @default.
- W2315880537 title "Clinical and laboratory findings in factor XI deficiency" @default.
- W2315880537 doi "https://doi.org/10.1016/s0031-3025(16)39365-5" @default.
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