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• W2315888930 abstract "You have accessJournal of UrologyImaging/Radiology: Uroradiology III1 Apr 2015MP17-10 EVALUATION OF PI-RADS CLASSIFICATION IN PREDICTION OF TUMOUR AGGRESSIVENESS – COMPARISON TO RADICAL PROSTATECTOMY SPECIMEN Angelika Borkowetz, Ivan Platzek, Marieta Toma, Stefan Zastrow, Michael Froehner, Rainer Koch, and Manfred Wirth Angelika BorkowetzAngelika Borkowetz More articles by this author , Ivan PlatzekIvan Platzek More articles by this author , Marieta TomaMarieta Toma More articles by this author , Stefan ZastrowStefan Zastrow More articles by this author , Michael FroehnerMichael Froehner More articles by this author , Rainer KochRainer Koch More articles by this author , and Manfred WirthManfred Wirth More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.852AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The Prostate Imaging and Reporting Data System (PI-RADS) is told to represent a decision-making support for targeted biopsy of tumour-suspicious lesions in multiparametric MRI (mpMRI) of the prostate. We examined the applicability of this classification by direct comparison of mpMRI and radical prostatectomy specimen (PrS). METHODS We enrolled 65 patients who underwent radical prostatectomy. In all patients, PCa was proven by the combination of transperineal MRI/ultrasound-fusion prostate biopsy and a systematic transrectal 12-core-biopsy previously. All patients were examined by 3Tesla mpMRI (T2-, diffusion (DWI, ADC)- and perfusion-weighted sequences) evaluated according to the criteria of the European Society of Urogenital Radiology. Tumour-suspicious lesions were classified according to the PI-RADS classification. MpMRI and whole-mount PrS were compared by a uro-radiologist and a uro-pathologist directly. The correlation of PI-RADS and Gleason Score (GS) was evaluated. RESULTS 112 lesions were detected in mpMRI (PI-RADS≤3: 59% (n=66); PI-RADS≥4 41% (n=46)). In PrS, 206 cancer foci were proven (GS=6: 26% (n=54); GS≥7: 74% (n=152)). PCa was detected in 89 (80%) lesions in mpMRI (GS=6: 13% (n=12), GS≥7: 87% (n=77)). The tumour detection rate in lesions classified as PI-RADS≥4 was 91% (42/46) and in those classified as PI-RADS≤3 it was 73% (48/66), (p=0.015). In detail, the detection rate was 66% (GS=6: 6%; GS≥7: 59%) in lesions with PI-RADS2 (n=17), 76% (GS=6: 18%; GS≥7: 57%) in those with PI-RADS3 (n=49), 87% (GS=6: 4%; GS≥7: 83%) in those with PI-RADS4 (n=30) and 100% (100% GS≥7) in those with PI-RADS5 (n=16). The area under the curve (AUC) for detection of tumours with GS≥7 was 0.646 (95% CI; 0.455-0.746). Cancer foci with visualization in mpMRI (n=89) were greater than those without detection in mpMRI (n=117) (mean 25 mm vs. 10 mm; p<0.001). CONCLUSIONS PI-RADS represents an applicable classification of tumour-suspicious lesions in mpMRI. PI-RADS≥4 is associated with a high detection rate of tumours with GS≥7. But due to a high portion of tumours with GS≥7, biopsy of lesions classified as PI-RADS3 should be considered furthermore. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e179-e180 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Angelika Borkowetz More articles by this author Ivan Platzek More articles by this author Marieta Toma More articles by this author Stefan Zastrow More articles by this author Michael Froehner More articles by this author Rainer Koch More articles by this author Manfred Wirth More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2315888930 title "MP17-10 EVALUATION OF PI-RADS CLASSIFICATION IN PREDICTION OF TUMOUR AGGRESSIVENESS – COMPARISON TO RADICAL PROSTATECTOMY SPECIMEN" @default.
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