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- W2315897057 abstract "<p>Heart rate variability (HRV ) parameters and hematological indices in rats under hypobaric hypoxia during<br />treatment by a thiazolidine derivative substance Les-589 (potassium salt of 3-(5-phenylpropeniliden rhodamine-3-<br />yl)-propanoic acid) were studied. Hypobaric hypoxia was developed in altitude chamber for 1 hour under conditions<br />identical height of 6000 m above sea level, 45 minutes after injection of Les-589. Thiotriazolin was applied as a<br />reference drug.<br />After one day after exposure to hypoxia, according to blood parameters and hematological indices, adaptive<br />response develops by the type of insufficient adaptation. The effect of the prior administration of Les-589, similar to<br />the effect of a reference drug Thiotriazolin, in the time of post-hypoxic period developed reactions of an increased<br />activation, which indicates a favorable course of adaptation.<br />Considering the parameters of HRV was found that prior administration of Les-589 within studied terms of posthypoxic<br />period leads to earlier and more effective recovery of various links of regulatory systems, compared with<br />hypoxia. This is consistent with an estimated type of adaptation processes, based on hematological parameters<br />and indices.</p>" @default.
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- W2315897057 date "2015-12-29" @default.
- W2315897057 modified "2023-09-27" @default.
- W2315897057 title "Effect of thiazolidine derivatives on heart rate variability (hrv) and blood parameters of experimental animals under hypobaric hypoxia" @default.
- W2315897057 doi "https://doi.org/10.11603/mcch.2410-681x.2015.v17.i4.5725" @default.
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