Matches in SemOpenAlex for { <https://semopenalex.org/work/W2315926133> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2315926133 endingPage "66" @default.
- W2315926133 startingPage "66" @default.
- W2315926133 abstract "Background: HIV associated neurocognitive disease (HAND) involves ongoing migration of blood associated monocytes into areas of disease. The migrant CD163 expressing macrophages implicated in HAND have recently been implicated in HIV associated atherosclerosis a growing problem in HIV infected patients including those with HAND. We describe a novel approach to AIDS related macrophage diseases using PA300 (MGBG; methylglyoxal bis(guanylhydrazone) dihydrochloride monohydrate), a formulated oral polyamine biosynthesis regulator (Pathologica, LLC, Burlingame CA). Methods: PA300 was evaluated for dose dependent responses in a) in vitro macrophage culture systems and b) a rhesus model of SIV encephalopathy. Results: PA300 blocked induction of monocyte differentiation into polarized macrophages, blocked HIV infection of macrophages and killed exposed HIV infected macrophages in vitro. (ED80: 0.3-1uM). Eight rhesus macaques were SIV-infected and CD8+ T lymphocyte depleted. At 21 days post-infection, a time when CNS disease would be apparent, animals were given PA300 (3mg/kg; n=2, 10mg/kg; n=2; 30mg/kg; n=2) or vehicle control (n=2). After one month of treatment: No evidence for CNS infection, macrophage infiltration or brain pathology was observed at the highest dose with intermediate efficacy at lower doses. SIV associated myocarditis was also reversed. Blood CD14+ cells showed no detectible SIV DNA at intermediate and high doses of PA300. Summary: PA300 is a novel macrophage differentiation regulator with additional activity against HIV infected macrophages. Treatment of macaques with SIV associated encephalopathy and myocarditis resulted in disease reversal and loss of infected macrophages in the brain and blood." @default.
- W2315926133 created "2016-06-24" @default.
- W2315926133 creator A5036909307 @default.
- W2315926133 creator A5053615892 @default.
- W2315926133 creator A5077047503 @default.
- W2315926133 creator A5080708954 @default.
- W2315926133 date "2013-04-01" @default.
- W2315926133 modified "2023-09-27" @default.
- W2315926133 title "ST106 Macrophage targeted therapy for AIDS" @default.
- W2315926133 doi "https://doi.org/10.1097/01.qai.0000429268.82844.52" @default.
- W2315926133 hasPublicationYear "2013" @default.
- W2315926133 type Work @default.
- W2315926133 sameAs 2315926133 @default.
- W2315926133 citedByCount "0" @default.
- W2315926133 crossrefType "journal-article" @default.
- W2315926133 hasAuthorship W2315926133A5036909307 @default.
- W2315926133 hasAuthorship W2315926133A5053615892 @default.
- W2315926133 hasAuthorship W2315926133A5077047503 @default.
- W2315926133 hasAuthorship W2315926133A5080708954 @default.
- W2315926133 hasBestOaLocation W23159261331 @default.
- W2315926133 hasConcept C126322002 @default.
- W2315926133 hasConcept C159047783 @default.
- W2315926133 hasConcept C167672396 @default.
- W2315926133 hasConcept C202751555 @default.
- W2315926133 hasConcept C203014093 @default.
- W2315926133 hasConcept C2775858924 @default.
- W2315926133 hasConcept C2776914184 @default.
- W2315926133 hasConcept C2778513237 @default.
- W2315926133 hasConcept C2779244956 @default.
- W2315926133 hasConcept C2779830541 @default.
- W2315926133 hasConcept C2780875844 @default.
- W2315926133 hasConcept C2781184567 @default.
- W2315926133 hasConcept C55493867 @default.
- W2315926133 hasConcept C71924100 @default.
- W2315926133 hasConcept C86803240 @default.
- W2315926133 hasConcept C8891405 @default.
- W2315926133 hasConceptScore W2315926133C126322002 @default.
- W2315926133 hasConceptScore W2315926133C159047783 @default.
- W2315926133 hasConceptScore W2315926133C167672396 @default.
- W2315926133 hasConceptScore W2315926133C202751555 @default.
- W2315926133 hasConceptScore W2315926133C203014093 @default.
- W2315926133 hasConceptScore W2315926133C2775858924 @default.
- W2315926133 hasConceptScore W2315926133C2776914184 @default.
- W2315926133 hasConceptScore W2315926133C2778513237 @default.
- W2315926133 hasConceptScore W2315926133C2779244956 @default.
- W2315926133 hasConceptScore W2315926133C2779830541 @default.
- W2315926133 hasConceptScore W2315926133C2780875844 @default.
- W2315926133 hasConceptScore W2315926133C2781184567 @default.
- W2315926133 hasConceptScore W2315926133C55493867 @default.
- W2315926133 hasConceptScore W2315926133C71924100 @default.
- W2315926133 hasConceptScore W2315926133C86803240 @default.
- W2315926133 hasConceptScore W2315926133C8891405 @default.
- W2315926133 hasIssue "Supplement 1" @default.
- W2315926133 hasLocation W23159261331 @default.
- W2315926133 hasLocation W23159261332 @default.
- W2315926133 hasOpenAccess W2315926133 @default.
- W2315926133 hasPrimaryLocation W23159261331 @default.
- W2315926133 hasRelatedWork W103895141 @default.
- W2315926133 hasRelatedWork W1999929128 @default.
- W2315926133 hasRelatedWork W2014064744 @default.
- W2315926133 hasRelatedWork W2055520368 @default.
- W2315926133 hasRelatedWork W2070119586 @default.
- W2315926133 hasRelatedWork W2334484009 @default.
- W2315926133 hasRelatedWork W2527849962 @default.
- W2315926133 hasRelatedWork W2790867122 @default.
- W2315926133 hasRelatedWork W2913126181 @default.
- W2315926133 hasRelatedWork W4220726644 @default.
- W2315926133 hasVolume "62" @default.
- W2315926133 isParatext "false" @default.
- W2315926133 isRetracted "false" @default.
- W2315926133 magId "2315926133" @default.
- W2315926133 workType "article" @default.