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- W2315929474 abstract "Despite the accumulating evidence supporting the health effects of anthocyanins, their plasma concentrations were found to be very low. However, 30 and 56% of cyanidin 3-glucoside (Cy-3-glc) and pelargonidin 3-glucoside (Pg-3-glc) were found as protocatechuic acid (PCA) and 4-hydroxybenzoic acid, respectively, in plasma following oral administration in humans. Second, 12.4% of 13C was recovered from urine and breath following oral ingestion of [13C]-Cy-3-glc in humans. The actual percentage of [13C]-Cy-3-glc absorbed across the gastrointestinal wall could be higher because of the involvement of enterohepatic recycling in the disposition of anthocyanins. In animal studies, high total urinary recoveries were found following oral ingestion of 14C-labeled anthocyanins. Third, anthocyanins seem to be efficiently absorbed following in situ gastric and intestinal perfusions in rats. Therefore, some anthocyanins could be efficiently absorbed from the gastrointestinal lumen, undergo extensive first-pass metabolism, and enter the systemic circulation as metabolites." @default.
- W2315929474 created "2016-06-24" @default.
- W2315929474 creator A5035410475 @default.
- W2315929474 date "2014-03-31" @default.
- W2315929474 modified "2023-10-02" @default.
- W2315929474 title "Some Anthocyanins Could Be Efficiently Absorbed across the Gastrointestinal Mucosa: Extensive Presystemic Metabolism Reduces Apparent Bioavailability" @default.
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- W2315929474 doi "https://doi.org/10.1021/jf405356b" @default.
- W2315929474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24650097" @default.
- W2315929474 hasPublicationYear "2014" @default.