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• W231599663 endingPage "957" @default.
• W231599663 startingPage "949" @default.
• W231599663 abstract "Abstract Granulocyte colony-stimulating factor (G-CSF) can elicit responses that include proliferation, granulocytic differentiation, and activation of cellular functions in target cells. The biochemical pathways responsible for transduction of these signals from the G-CSF receptor (G-CSFR) have not been defined. In this report, we show that, in murine (NFS-60) and human (OCI-AML 1) myeloid leukemia cell lines and in murine pro-B-lymphocytic cells, BAF/B03, transfected with the murine G- CSFR, proliferative responses to G-CSF are associated with rapid activation of p42 and p44 MAP kinases and p21ras. Truncation of the cytoplasmic portion of the murine G-CSFR at residue 646 but not at residue 739 abolished G-CSF-induced stimulation of cellular proliferation as well as activation of MAP kinase and p21ras in transfected BAF/B03 cells. G-CSF-induced granulocytic differentiation of the murine leukemic cell line 32DC13(G) occurred in the absence of detectable activation of p42 MAP kinase. Nonproliferative responses to G-CSF in the human promyelocytic cell line HL-60 and in human neutrophils were similarly associated with no MAP kinase activation. These results imply that differing cellular effects of G-CSF may be involve the recruitment of differing signal transduction pathways with the p21ras/MAP kinase pathway being limited to proliferative responses." @default.
• W231599663 created "2016-06-24" @default.
• W231599663 creator A5012199513 @default.
• W231599663 creator A5041206856 @default.
• W231599663 creator A5041877598 @default.
• W231599663 date "1994-02-15" @default.
• W231599663 modified "2023-09-28" @default.
• W231599663 title "Proliferative but not nonproliferative responses to granulocyte colony- stimulating factor are associated with rapid activation of the p21ras/MAP kinase signalling pathway" @default.
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• W231599663 doi "https://doi.org/10.1182/blood.v83.4.949.949" @default.
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• W231599663 hasPublicationYear "1994" @default.
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