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• W2316048374 abstract "The Eker rat is a model for human tuberous sclerosis (TSC) caused by a mutation in the Tsc2 gene. We describe here histological and immunohistochemical findings of the brain lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further confirmed the value of this animal model as a tool for investigating the molecular pathology of tuberous sclerosis. On the other hand, the rat anaplastic ganglioglioma had features of a malignant neoplasm that are absent from human subependymal giant cell astrocytomas." @default.
• W2316048374 created "2016-06-24" @default.
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• W2316048374 date "2000-03-01" @default.
• W2316048374 modified "2023-10-15" @default.
• W2316048374 title "Novel Cerebral Lesions in the Eker Rat Model of Tuberous Sclerosis: Cortical Tuber and Anaplastic Ganglioglioma" @default.
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• W2316048374 doi "https://doi.org/10.1093/jnen/59.3.188" @default.
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