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- W2316062356 abstract "An expedient asymmetric synthesis of TRPV1 antagonist 1 has been developed and demonstrated on multikilogram scale. The enabling route to 1 is detailed herein and characterized by the following key transformations: an aldol-cyclodehydration sequence to install the chromanone, and an auxiliary-mediated diastereoselective reductive amination." @default.
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- W2316062356 date "2014-01-10" @default.
- W2316062356 modified "2023-09-27" @default.
- W2316062356 title "Asymmetric Synthesis of a TRPV1 Antagonist via <i>tert</i>-Butanesulfinamide-Directed Reductive Amination with a Chromanone" @default.
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- W2316062356 doi "https://doi.org/10.1021/op400184f" @default.
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