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- W2316089957 abstract "Prevention of functional impairment of platelet during storage was tried by using modified poly (vinylchloride) bags, and the mechanism of functional impairment is discussed. Platelet concentrates were stored in glow-discharge treated (GD) and/or hydrogel (PEO) coated bags. Platelets stored in bags in which plasticizer (DEHP) leakage was prevented by GD, maintained functions (aggregability and hypotonic shock response) well. DEHP was added to fresh PRP and the effects of DEHP were examined. Cytoplasmic Ca2+ (Cyt-Ca2+), membrane-associated Ca2+ (M-Ca2+) and membrane potential (MP) increase during storage. Although MP and Cyt-Ca2+ were not affected by DEHP, M-Ca2+ had increased after incubation at 22°C for 24 hours. The degree of increase of Cyt-Ca2+ in platelets stored in PEO bags was lower than that in platelets in non-coated bag. The relationship between Ca2+ distribution in resting platelets and function is not clear. However, the results in this paper suggest the possibility that modification of bag is effective on prevention of platelet change during storage." @default.
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- W2316089957 date "1986-01-01" @default.
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- W2316089957 title "Prevention of functional impairment of platelet using modified blood bags." @default.
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- W2316089957 doi "https://doi.org/10.2491/jjsth1970.17.521" @default.
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