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• W2316097708 abstract "Background Promising data has been recently published about the role of contrast-enhanced ultrasound (CEU) in the diagnosis and follow up of Takayasu arteritis (TA) -[1][1],[2][2]-Objectives To assess the role of CEU examination of the carotid artery in patients with large vessel vasculitis (LVV) compared to Positron Emission Tomography (PET).Methods 10 patients (8 TA,[2][2] LVV, mean age 46±19y, mean disease duration 3.9±3.1y ) were contemporary evaluated with total body PET and carotid arteries US gray scale and CEU (Esaote MyLab70, 13-5MH linear probe, contrast agent Sonovue). All the patients underwent complete clinical examination and laboratory determination of acute phase reactants. Imaging results were reported using a semiquantitave score ranging from 0 (no activity) to 3 (high activity). Comparison between the two tests were made using Cohen K test.Results At US gray scale examination 8/10 patients have high intima/media thickness (mean 1,5 mm ±0.46). In patients with positive contrast enhanced ultrasound themean carotid intima-media thickness was 2,1mm ±0.48, while patients withnegative contrast enhanced ultrasound presented a mean wall thickness of 0,9mm ±0.47 (P = 0.009). There was no significant differences in clinical, demographic and laboratory data between patients with active and inactive disease. All the 4 patients with high/medium carotid activity at PET examination presented positive (activity score >1) CEU. Five of the 6 patients with low/absent PET signal have negative (activity score <2) CEU (K test = 0.800, good concordance).Conclusions CEU have a good concordance with PET. These results outline the potential role of CEU to be used in monitoring disease activity and response to treatment in LVV.References 1. Magnoni M. et al.; Assessment of Takayasu arteritis activity by carotid contrast-enhanced ultrasound. Circ Cardiovasc Imaging. 2011 Mar;4(2):e1-2.2. Giordana P et al.; Contrast-enhanced ultrasound of carotid artery wall in Takayasu disease: first evidence of application in diagnosis and monitoring of response to treatment. Circulation. 2011;124:245-7.Disclosure of Interest : None Declared [1]: #p-6 [2]: #p-7" @default.
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• W2316097708 date "2013-06-01" @default.
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• W2316097708 title "FRI0362 Contrast-enhanced ultrasound of the sovraortic arteries: the potential role in monitoring disease activity and response to treatment in large vessel vasculitis." @default.
• W2316097708 doi "https://doi.org/10.1136/annrheumdis-2013-eular.1489" @default.
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