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• W2316102780 endingPage "5493" @default.
• W2316102780 startingPage "5484" @default.
• W2316102780 abstract "We report direct, concurrent measurements of the forces and currents associated with the translocation of a single-stranded DNA molecule tethered to the tip of an atomic force microscope (AFM) cantilever through synthetic pores with topagraphies comparable to the DNA. These measurements were performed to gauge the signal available for sequencing and the electric force required to impel a single molecule through synthetic nanopores ranging from 1.0 to 3.5 nm in diameter in silicon nitride membranes 6-10 nm thick. The measurements revealed that a molecule can slide relatively frictionlessly through a pore, but regular fluctuations are observed intermittently in the force (and the current) every 0.35-0.72 nm, which are attributed to individual nucleotides translating through the nanopore in a turnstile-like motion." @default.
• W2316102780 created "2016-06-24" @default.
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• W2316102780 date "2014-05-28" @default.
• W2316102780 modified "2023-09-26" @default.
• W2316102780 title "Direct, Concurrent Measurements of the Forces and Currents Affecting DNA in a Nanopore with Comparable Topography" @default.
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• W2316102780 doi "https://doi.org/10.1021/nn405331t" @default.
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• W2316102780 hasPublicationYear "2014" @default.
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