Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316103399> ?p ?o ?g. }
- W2316103399 endingPage "630" @default.
- W2316103399 startingPage "615" @default.
- W2316103399 abstract "Simply providing anticoagulation therapy is not as straightforward of a solution in cancer patients who have concurrent thrombocytopenia owing to the increased risk of bleeding complications. Currently, few guidelines are in place to assist clinicians in safely managing thrombocytopenic cancer patients on anticoagulation. The purpose of this review is to critically examine the available body of biomedical literature surrounding anticoagulant use against the backdrop of cancer-related thrombocytopenia in adult patients. Available evidence for the use of parenteral anticoagulants (low molecular weight heparins, unfractionated heparin, pentasaccharides, and direct thrombin inhibitors) and oral anticoagulants (vitamin K antagonists and novel oral anticoagulants) in thrombocytopenic cancer patients is described. The review revealed many inconsistencies between reports on this topic, which made it difficult to draw firm conclusions as to, for example, the ideal well tolerated anticoagulant dose in thrombocytopenic cancer patients? Intriguingly, critical clinical information including (but not limited) patient platelet nadirs, platelet counts during bleeding episodes, and platelet transfusion support was absent from a not-so-insignificant number of publications. Despite these shortcomings, the review sets out to formulate recommendations on the management of anticoagulation, at prophylactic or treatment doses, in adult cancer patients who also have concurrent thrombocytopenia. It also enlists a call for the medical community, by mapping select clinical guideposts, for further research in this setting. With the inclusion of these criteria in future studies, only then formal recommendations on the ideal safe dosage of anticoagulants in cancer patients, based on solid evidence, are conceived." @default.
- W2316103399 created "2016-06-24" @default.
- W2316103399 creator A5010706893 @default.
- W2316103399 creator A5015794517 @default.
- W2316103399 creator A5023996851 @default.
- W2316103399 date "2016-09-01" @default.
- W2316103399 modified "2023-09-24" @default.
- W2316103399 title "‘Sailing in troubled waters’" @default.
- W2316103399 cites W133525775 @default.
- W2316103399 cites W1527283637 @default.
- W2316103399 cites W1527739777 @default.
- W2316103399 cites W174830320 @default.
- W2316103399 cites W1955610473 @default.
- W2316103399 cites W1969669677 @default.
- W2316103399 cites W1972619703 @default.
- W2316103399 cites W1973509710 @default.
- W2316103399 cites W1978808454 @default.
- W2316103399 cites W1979903575 @default.
- W2316103399 cites W1982125716 @default.
- W2316103399 cites W1984207751 @default.
- W2316103399 cites W1984833612 @default.
- W2316103399 cites W1984836071 @default.
- W2316103399 cites W1984947761 @default.
- W2316103399 cites W1987458494 @default.
- W2316103399 cites W1989929076 @default.
- W2316103399 cites W1993635291 @default.
- W2316103399 cites W1996156310 @default.
- W2316103399 cites W1996650797 @default.
- W2316103399 cites W2006233991 @default.
- W2316103399 cites W2010481138 @default.
- W2316103399 cites W2013029269 @default.
- W2316103399 cites W2015225227 @default.
- W2316103399 cites W2021372244 @default.
- W2316103399 cites W2023158584 @default.
- W2316103399 cites W2023807902 @default.
- W2316103399 cites W2025996170 @default.
- W2316103399 cites W2026895719 @default.
- W2316103399 cites W2031799746 @default.
- W2316103399 cites W2034255966 @default.
- W2316103399 cites W2034850919 @default.
- W2316103399 cites W2035196068 @default.
- W2316103399 cites W2037300212 @default.
- W2316103399 cites W2039223350 @default.
- W2316103399 cites W2040800118 @default.
- W2316103399 cites W2041113507 @default.
- W2316103399 cites W2041283702 @default.
- W2316103399 cites W2044889252 @default.
- W2316103399 cites W2045391434 @default.
- W2316103399 cites W2050812778 @default.
- W2316103399 cites W2056782206 @default.
- W2316103399 cites W2061293556 @default.
- W2316103399 cites W2064575059 @default.
- W2316103399 cites W2070112905 @default.
- W2316103399 cites W2070741400 @default.
- W2316103399 cites W2073237059 @default.
- W2316103399 cites W2076827228 @default.
- W2316103399 cites W2077472453 @default.
- W2316103399 cites W2077695446 @default.
- W2316103399 cites W2080147366 @default.
- W2316103399 cites W2097365769 @default.
- W2316103399 cites W2100184560 @default.
- W2316103399 cites W2101131613 @default.
- W2316103399 cites W2101273537 @default.
- W2316103399 cites W2102163277 @default.
- W2316103399 cites W2103419160 @default.
- W2316103399 cites W2106763942 @default.
- W2316103399 cites W2113020324 @default.
- W2316103399 cites W2113887116 @default.
- W2316103399 cites W2115019673 @default.
- W2316103399 cites W2116275499 @default.
- W2316103399 cites W2116495690 @default.
- W2316103399 cites W2119736254 @default.
- W2316103399 cites W2121599032 @default.
- W2316103399 cites W2124101267 @default.
- W2316103399 cites W2132909060 @default.
- W2316103399 cites W2133760135 @default.
- W2316103399 cites W2134683286 @default.
- W2316103399 cites W2137283681 @default.
- W2316103399 cites W2138438886 @default.
- W2316103399 cites W2141100626 @default.
- W2316103399 cites W2144182139 @default.
- W2316103399 cites W2144666882 @default.
- W2316103399 cites W2147865792 @default.
- W2316103399 cites W2152672882 @default.
- W2316103399 cites W2152957190 @default.
- W2316103399 cites W2154321941 @default.
- W2316103399 cites W2160635879 @default.
- W2316103399 cites W2314836782 @default.
- W2316103399 cites W2318098727 @default.
- W2316103399 cites W2332840152 @default.
- W2316103399 cites W2418681116 @default.
- W2316103399 cites W2980172952 @default.
- W2316103399 cites W4210997017 @default.
- W2316103399 cites W4238555341 @default.
- W2316103399 cites W4247355438 @default.
- W2316103399 cites W4251583248 @default.
- W2316103399 cites W62537 @default.
- W2316103399 doi "https://doi.org/10.1097/mbc.0000000000000539" @default.