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- W2316178064 abstract "<h3>Objective</h3> To determine the relationship between human fibroblast growth factor 21 (FGF21) and thyroid stimulating hormone (TSH) by testing the level of FGF21, lipid metabolism, and carbohydrate metabolism-related indices, as well as the level of TSH, among metabolic syndrome-free patients with normal physical examination results. <h3>Methods</h3> An enzyme-linked immunosorbent assay (ELISA) was used to test the levels of serum FGF21 and free fatty acids (FFA) in metabolic syndrome-free patients with normal physical examination results, and electrochemiluminescence (ECLIA) was used to measure TSH, thyroglobulin antibodies (TGAbs), and thyroid peroxidase antibody (TPOAb) levels. <h3>Results</h3> Three hundred fifty-six metabolic syndrome-free patients (116 males and 240 females; average age, 43±13 years) with normal physical examination results were enrolled. Among the patients with normal physical examination results, FGF21 had a weak relationship with obesity indices, such as the waist circumference (r=0.110, <i>P</i>=0.038), the waist-to-hip ratio (r=0.119, <i>P</i>=0.025), and the triglycerides level (TG; r=0.302, <i>P</i>=0.000), and a weak relationship with blood lipid levels, such as total cholesterol (TCHO; r=0.113, <i>P</i>=0.012) and low-density lipoprotein-cholesterol (LDL-C; r=0.175, <i>P</i>=0.001), but no relationship with TSH (r=–0.023, <i>P</i>=0.666). In addition, the FGF21 levels in thyroid autoantibody-positive and -negative groups were not significantly different. <h3>Conclusion</h3> Among the metabolic syndrome-free patients with normal physical examination results, FGF21 has no apparent relationship with TSH or thyroid autoimmunity." @default.
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- W2316178064 date "2014-09-01" @default.
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- W2316178064 title "Relationship between fibroblast growth factor 21 and thyroid stimulating hormone in healthy subjects without components of metabolic syndrome" @default.
- W2316178064 doi "https://doi.org/10.15212/fmch.2014.0118" @default.
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