Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316181400> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2316181400 endingPage "50" @default.
- W2316181400 startingPage "43" @default.
- W2316181400 abstract "Reduced expression of E-cadherin (E-cad), a transmembrane glycoprotein, is associated with loss of differentiation, acquisition of an invasive phenotype, and an unfavorable prognosis in carcinomas from several sites. We used immunohistochemistry to study the expression of E-cad in 50 adenoid cystic carcinomas (ACCs) in salivary glands to evaluate correlations with clinicopathologic parameters and patient survival. Absent or low E-cad expression was observed more frequently in solid than in cribriform or tubular carcinomas. E-cad expression also was significantly correlated with histologic grade and the growth pattern. In addition, ACCs showing low or absent E-cad expression were more frequently larger than 4 cm in diameter, and distant metastases developed more frequently. Reduced expression correlated with shorter disease-free intervals and actuarial survival rates. Univariate and multivariate analysis identified tumor stage and E-cad expression as the only 2 parameters predictive of the disease-free interval. E-cad expression and tumor stage, grade, and type of growth were significant prognostic factors for survival in univariate analysis, while tumor stage, type of growth, and E-cad expression were the only significant covariates in multivariate analysis. These findings indicate that the loss of E-cad has an important role in the natural history of ACC, as it is associated with loss of differentiation and development of metastases. We also provide evidence that E-cad expression is an independent indicator of clinical aggressiveness in patients with ACC, together with clinical stage and type of growth at the periphery of the tumor." @default.
- W2316181400 created "2016-06-24" @default.
- W2316181400 creator A5012092787 @default.
- W2316181400 creator A5014237354 @default.
- W2316181400 creator A5026919359 @default.
- W2316181400 creator A5037827357 @default.
- W2316181400 creator A5050768767 @default.
- W2316181400 creator A5073950636 @default.
- W2316181400 date "1999-01-01" @default.
- W2316181400 modified "2023-09-27" @default.
- W2316181400 title "Reduced E-Cadherin Expression Correlates with Unfavorable Prognosis in Adenoid Cystic Carcinoma of Salivary Glands of the Oral Cavity" @default.
- W2316181400 doi "https://doi.org/10.1093/ajcp/111.1.43" @default.
- W2316181400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9894453" @default.
- W2316181400 hasPublicationYear "1999" @default.
- W2316181400 type Work @default.
- W2316181400 sameAs 2316181400 @default.
- W2316181400 citedByCount "47" @default.
- W2316181400 countsByYear W23161814002012 @default.
- W2316181400 countsByYear W23161814002014 @default.
- W2316181400 countsByYear W23161814002015 @default.
- W2316181400 countsByYear W23161814002017 @default.
- W2316181400 countsByYear W23161814002020 @default.
- W2316181400 countsByYear W23161814002021 @default.
- W2316181400 countsByYear W23161814002022 @default.
- W2316181400 crossrefType "journal-article" @default.
- W2316181400 hasAuthorship W2316181400A5012092787 @default.
- W2316181400 hasAuthorship W2316181400A5014237354 @default.
- W2316181400 hasAuthorship W2316181400A5026919359 @default.
- W2316181400 hasAuthorship W2316181400A5037827357 @default.
- W2316181400 hasAuthorship W2316181400A5050768767 @default.
- W2316181400 hasAuthorship W2316181400A5073950636 @default.
- W2316181400 hasBestOaLocation W23161814001 @default.
- W2316181400 hasConcept C126322002 @default.
- W2316181400 hasConcept C142724271 @default.
- W2316181400 hasConcept C143998085 @default.
- W2316181400 hasConcept C144301174 @default.
- W2316181400 hasConcept C146357865 @default.
- W2316181400 hasConcept C151730666 @default.
- W2316181400 hasConcept C204232928 @default.
- W2316181400 hasConcept C2777546739 @default.
- W2316181400 hasConcept C2779231225 @default.
- W2316181400 hasConcept C2781163425 @default.
- W2316181400 hasConcept C38180746 @default.
- W2316181400 hasConcept C71924100 @default.
- W2316181400 hasConcept C86803240 @default.
- W2316181400 hasConceptScore W2316181400C126322002 @default.
- W2316181400 hasConceptScore W2316181400C142724271 @default.
- W2316181400 hasConceptScore W2316181400C143998085 @default.
- W2316181400 hasConceptScore W2316181400C144301174 @default.
- W2316181400 hasConceptScore W2316181400C146357865 @default.
- W2316181400 hasConceptScore W2316181400C151730666 @default.
- W2316181400 hasConceptScore W2316181400C204232928 @default.
- W2316181400 hasConceptScore W2316181400C2777546739 @default.
- W2316181400 hasConceptScore W2316181400C2779231225 @default.
- W2316181400 hasConceptScore W2316181400C2781163425 @default.
- W2316181400 hasConceptScore W2316181400C38180746 @default.
- W2316181400 hasConceptScore W2316181400C71924100 @default.
- W2316181400 hasConceptScore W2316181400C86803240 @default.
- W2316181400 hasIssue "1" @default.
- W2316181400 hasLocation W23161814001 @default.
- W2316181400 hasLocation W23161814002 @default.
- W2316181400 hasOpenAccess W2316181400 @default.
- W2316181400 hasPrimaryLocation W23161814001 @default.
- W2316181400 hasRelatedWork W1979199368 @default.
- W2316181400 hasRelatedWork W2027051457 @default.
- W2316181400 hasRelatedWork W2148994442 @default.
- W2316181400 hasRelatedWork W2330497438 @default.
- W2316181400 hasRelatedWork W2352281397 @default.
- W2316181400 hasRelatedWork W2355525666 @default.
- W2316181400 hasRelatedWork W2411442805 @default.
- W2316181400 hasRelatedWork W2898239264 @default.
- W2316181400 hasRelatedWork W2983424129 @default.
- W2316181400 hasRelatedWork W3087682285 @default.
- W2316181400 hasVolume "111" @default.
- W2316181400 isParatext "false" @default.
- W2316181400 isRetracted "false" @default.
- W2316181400 magId "2316181400" @default.
- W2316181400 workType "article" @default.