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- W2316181775 abstract "ABSTRACT The study describes an analysis of the development of mouse embryos halved at the 2-cell stage by the destruction of one blastomere, in comparison with control embryos of parallel derivation, at 2·5–13·5 dayspostcoitum. The results showed that: (1) half embryos achieve size regulation some time between 7·5 and 10·5 days; (2) there is an indication that by 13·5 days half embryos may have again dropped back significantly in size relative to controls; (3) preregulation half embryos are slightly retarded developmentally, but this does not wholly account for their smaller size: morphogenesis is not size-dependent; (4) early postimplantation half embryos contain a significantly decreased proportion of inner cell mass derivatives and increased proportion of trophectoderm derivatives when compared with controls. A comparison is also made between the up-regulation of half embryos and the downregulation of aggregate embryos, and it is suggested that size regulation may occur by delaying a change in the normal growth rate." @default.
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- W2316181775 date "1986-11-01" @default.
- W2316181775 modified "2023-09-26" @default.
- W2316181775 title "Size regulation in the mouse embryo: II. The development of half embryos" @default.
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- W2316181775 doi "https://doi.org/10.1242/dev.98.1.209" @default.
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