Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316183713> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2316183713 abstract "Changes in the serotonergic system are suspected to play a role in stress-induced neuropathologies and 5-HT neurons in the dorsal raphe nucleus (DRN) are activated by stress. We quantified gene expression in the DRN of male rats subjected to social stress for 5 weeks, and in rats that were stressed and at the same time treated with citalopram (4 weeks).–Subtractive hybridization was performed to clone differentially expressed sequences. Quantitative Real-time PCR showed stress-induced upregulation of two genes related to neurotransmission, one gene involved in neuroplasticity and one related to regulation of transcription. The chronic citalopram treatment normalized expression of these genes. Expression of genes directly related to 5-HT neurotransmission were not affected by chronic social stress. Citalopram downregulated tryptophan hydroxylase 2 in stressed and non-stressed rats, but downregulated the 5-HT1A autoreceptor only in the stressed rats.–In conclusion, chronic stress leads to changes in expression of genes related to neurotransmission/neuroplasticity in the DRN. In contrast, expression of genes directly related to 5-HT neurotransmission appears relatively stable after the 5 weeks of stress. Citalopram does not directly reverse the neuromolecular processes induced by chronic stress in the rat DRN but leads to other changes in gene expression. Supported by DFG Research Center Molecular Physiology of the Brain (CMPB)." @default.
- W2316183713 created "2016-06-24" @default.
- W2316183713 creator A5015342296 @default.
- W2316183713 creator A5033883651 @default.
- W2316183713 creator A5036290198 @default.
- W2316183713 creator A5038124859 @default.
- W2316183713 creator A5049092849 @default.
- W2316183713 creator A5051340444 @default.
- W2316183713 date "2005-09-01" @default.
- W2316183713 modified "2023-09-25" @default.
- W2316183713 title "Gene regulation in the dorsal raphe nucleus during chronic social stress and citalopram treatment" @default.
- W2316183713 doi "https://doi.org/10.1055/s-2005-918682" @default.
- W2316183713 hasPublicationYear "2005" @default.
- W2316183713 type Work @default.
- W2316183713 sameAs 2316183713 @default.
- W2316183713 citedByCount "0" @default.
- W2316183713 crossrefType "journal-article" @default.
- W2316183713 hasAuthorship W2316183713A5015342296 @default.
- W2316183713 hasAuthorship W2316183713A5033883651 @default.
- W2316183713 hasAuthorship W2316183713A5036290198 @default.
- W2316183713 hasAuthorship W2316183713A5038124859 @default.
- W2316183713 hasAuthorship W2316183713A5049092849 @default.
- W2316183713 hasAuthorship W2316183713A5051340444 @default.
- W2316183713 hasConcept C104317684 @default.
- W2316183713 hasConcept C126322002 @default.
- W2316183713 hasConcept C134018914 @default.
- W2316183713 hasConcept C150194340 @default.
- W2316183713 hasConcept C169760540 @default.
- W2316183713 hasConcept C170493617 @default.
- W2316183713 hasConcept C200170125 @default.
- W2316183713 hasConcept C2775864247 @default.
- W2316183713 hasConcept C2777490545 @default.
- W2316183713 hasConcept C2778654844 @default.
- W2316183713 hasConcept C2779999352 @default.
- W2316183713 hasConcept C32610206 @default.
- W2316183713 hasConcept C37000724 @default.
- W2316183713 hasConcept C47611674 @default.
- W2316183713 hasConcept C54355233 @default.
- W2316183713 hasConcept C71924100 @default.
- W2316183713 hasConcept C8439214 @default.
- W2316183713 hasConcept C86803240 @default.
- W2316183713 hasConceptScore W2316183713C104317684 @default.
- W2316183713 hasConceptScore W2316183713C126322002 @default.
- W2316183713 hasConceptScore W2316183713C134018914 @default.
- W2316183713 hasConceptScore W2316183713C150194340 @default.
- W2316183713 hasConceptScore W2316183713C169760540 @default.
- W2316183713 hasConceptScore W2316183713C170493617 @default.
- W2316183713 hasConceptScore W2316183713C200170125 @default.
- W2316183713 hasConceptScore W2316183713C2775864247 @default.
- W2316183713 hasConceptScore W2316183713C2777490545 @default.
- W2316183713 hasConceptScore W2316183713C2778654844 @default.
- W2316183713 hasConceptScore W2316183713C2779999352 @default.
- W2316183713 hasConceptScore W2316183713C32610206 @default.
- W2316183713 hasConceptScore W2316183713C37000724 @default.
- W2316183713 hasConceptScore W2316183713C47611674 @default.
- W2316183713 hasConceptScore W2316183713C54355233 @default.
- W2316183713 hasConceptScore W2316183713C71924100 @default.
- W2316183713 hasConceptScore W2316183713C8439214 @default.
- W2316183713 hasConceptScore W2316183713C86803240 @default.
- W2316183713 hasIssue "05" @default.
- W2316183713 hasLocation W23161837131 @default.
- W2316183713 hasOpenAccess W2316183713 @default.
- W2316183713 hasPrimaryLocation W23161837131 @default.
- W2316183713 hasRelatedWork W1976336543 @default.
- W2316183713 hasRelatedWork W1984841954 @default.
- W2316183713 hasRelatedWork W1988040684 @default.
- W2316183713 hasRelatedWork W2046214599 @default.
- W2316183713 hasRelatedWork W2119684369 @default.
- W2316183713 hasRelatedWork W2522815781 @default.
- W2316183713 hasRelatedWork W2960064742 @default.
- W2316183713 hasRelatedWork W3031870968 @default.
- W2316183713 hasRelatedWork W2183507364 @default.
- W2316183713 hasRelatedWork W2473253526 @default.
- W2316183713 hasVolume "38" @default.
- W2316183713 isParatext "false" @default.
- W2316183713 isRetracted "false" @default.
- W2316183713 magId "2316183713" @default.
- W2316183713 workType "article" @default.