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- W2316192672 abstract "The magnetic technique for sentinel node biopsy provides a radioisotope-free alternative for staging breast cancer. It requires refinementto reduce “residual iron content” at injection sites by maximising lymphatic uptake to prevent “void artefacts” on magnetic resonanceimaging (MRI), which could adversely affect clinical use. The site and timing of injection of magnetic tracer was evaluated in a murinetumour model (right hind limb) in 24 wild type mice. Right-sided intratumoural and left sided subcutaneous injection of magnetic tracer andassessment of nodal iron uptake on MRI, surgical excision and histopathological grading at time frames up to 24 hours were performed.Rapid iron uptake on MRI, smaller “void artefacts”(P < 0.001) and a significant increase in iron content with time were identified in thesubcutaneous injection group (r = 0.937; P < 0.001).Subcutaneous injection and increasing delay between tracer injection and surgery isbeneficial for lymphatic iron uptake." @default.
- W2316192672 created "2016-06-24" @default.
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- W2316192672 date "2016-05-01" @default.
- W2316192672 modified "2023-10-03" @default.
- W2316192672 title "Magnetic sentinel lymph node biopsy in a murine tumour model" @default.
- W2316192672 doi "https://doi.org/10.1016/j.ejso.2016.02.148" @default.
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