Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316200901> ?p ?o ?g. }
- W2316200901 endingPage "1858" @default.
- W2316200901 startingPage "1840" @default.
- W2316200901 abstract "Autophagy and the ubiquitin–proteasome pathway (UPP) are the major protein degradation systems in eukaryotic cells. Whereas the former mediate a bulk nonspecific degradation, the UPP allows a rapid degradation of specific proteins. Both systems have been shown to play a role in tumorigenesis, and the interest in developing therapeutic agents inhibiting protein degradation is steadily growing. However, emerging data point to a critical role for autophagy in cellular senescence, an established tumor suppressor mechanism. Recently, a selective protein degradation process mediated by the UPP was also shown to contribute to the senescence phenotype. This process is tightly regulated by E3 ubiquitin ligases, deubiquitinases, and several post-translational modifications of target proteins. Illustrating the complexity of UPP, more than 600 human genes have been shown to encode E3 ubiquitin ligases, a number which exceeds that of the protein kinases. Nevertheless, our knowledge of proteasome-dependent protein degradation as a regulated process in cellular contexts such as cancer and senescence remains very limited. Here we discuss the implications of protein degradation in senescence and attempt to relate this function to the protein degradation pattern observed in cancer cells." @default.
- W2316200901 created "2016-06-24" @default.
- W2316200901 creator A5024534729 @default.
- W2316200901 creator A5064406116 @default.
- W2316200901 creator A5067092778 @default.
- W2316200901 creator A5084718558 @default.
- W2316200901 creator A5084890700 @default.
- W2316200901 date "2014-05-27" @default.
- W2316200901 modified "2023-10-02" @default.
- W2316200901 title "Cellular senescence and protein degradation" @default.
- W2316200901 cites W1528256651 @default.
- W2316200901 cites W1538085254 @default.
- W2316200901 cites W1548932088 @default.
- W2316200901 cites W1784425676 @default.
- W2316200901 cites W1868560008 @default.
- W2316200901 cites W1895463703 @default.
- W2316200901 cites W1948543785 @default.
- W2316200901 cites W1950397895 @default.
- W2316200901 cites W1963927300 @default.
- W2316200901 cites W1964021682 @default.
- W2316200901 cites W1964596502 @default.
- W2316200901 cites W1964719993 @default.
- W2316200901 cites W1965305243 @default.
- W2316200901 cites W1965493795 @default.
- W2316200901 cites W1966327560 @default.
- W2316200901 cites W1968074226 @default.
- W2316200901 cites W1969649885 @default.
- W2316200901 cites W1969722360 @default.
- W2316200901 cites W1970430170 @default.
- W2316200901 cites W1970891016 @default.
- W2316200901 cites W1971223620 @default.
- W2316200901 cites W1972378799 @default.
- W2316200901 cites W1972655555 @default.
- W2316200901 cites W1972780353 @default.
- W2316200901 cites W1973300568 @default.
- W2316200901 cites W1973633445 @default.
- W2316200901 cites W1973857401 @default.
- W2316200901 cites W1974868752 @default.
- W2316200901 cites W1976295398 @default.
- W2316200901 cites W1976635482 @default.
- W2316200901 cites W1976807210 @default.
- W2316200901 cites W1978818809 @default.
- W2316200901 cites W1978888457 @default.
- W2316200901 cites W1980515769 @default.
- W2316200901 cites W1981188497 @default.
- W2316200901 cites W1981598092 @default.
- W2316200901 cites W1982695619 @default.
- W2316200901 cites W1983594275 @default.
- W2316200901 cites W1984671542 @default.
- W2316200901 cites W1985124617 @default.
- W2316200901 cites W1987142903 @default.
- W2316200901 cites W1987944461 @default.
- W2316200901 cites W1988031203 @default.
- W2316200901 cites W1988319710 @default.
- W2316200901 cites W1990461051 @default.
- W2316200901 cites W1990619980 @default.
- W2316200901 cites W1991582633 @default.
- W2316200901 cites W1992724001 @default.
- W2316200901 cites W1992934869 @default.
- W2316200901 cites W1993571663 @default.
- W2316200901 cites W1993676104 @default.
- W2316200901 cites W1994218254 @default.
- W2316200901 cites W1994823586 @default.
- W2316200901 cites W1994924724 @default.
- W2316200901 cites W1995575524 @default.
- W2316200901 cites W1997789212 @default.
- W2316200901 cites W1998104906 @default.
- W2316200901 cites W1999353132 @default.
- W2316200901 cites W1999801453 @default.
- W2316200901 cites W2000872564 @default.
- W2316200901 cites W2001591494 @default.
- W2316200901 cites W2004273407 @default.
- W2316200901 cites W2005664674 @default.
- W2316200901 cites W2006429681 @default.
- W2316200901 cites W2007244362 @default.
- W2316200901 cites W2007872313 @default.
- W2316200901 cites W2008374448 @default.
- W2316200901 cites W2008797552 @default.
- W2316200901 cites W2009940846 @default.
- W2316200901 cites W2010417927 @default.
- W2316200901 cites W2010737830 @default.
- W2316200901 cites W2011656809 @default.
- W2316200901 cites W2012173754 @default.
- W2316200901 cites W2012971149 @default.
- W2316200901 cites W2013566223 @default.
- W2316200901 cites W2016515708 @default.
- W2316200901 cites W2019276374 @default.
- W2316200901 cites W2019845267 @default.
- W2316200901 cites W2021242983 @default.
- W2316200901 cites W2021460489 @default.
- W2316200901 cites W2021536610 @default.
- W2316200901 cites W2022531767 @default.
- W2316200901 cites W2023542289 @default.
- W2316200901 cites W2024449289 @default.
- W2316200901 cites W2025743107 @default.
- W2316200901 cites W2025773387 @default.
- W2316200901 cites W2027085235 @default.
- W2316200901 cites W2027253055 @default.