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- W2316242578 abstract "Abstract Chorioamnionitis is associated with preterm labor and fetal inflammatory response syndrome (FIRS), causing fetal organ injury and morbidity, particularly in extremely premature infants. However, the effects of inflammation on the fetal immune system remain poorly understood, due to the difficulty of studying immune development in infants. Therefore, we used the model of intra-amniotic LPS administered at ∼80% gestation in rhesus monkeys to cause chorioamnionitis and FIRS that is similar in human pathology. Importantly, the frequency of IL-17+ and IL-22+ CD4+ T cells increased in the spleen of LPS-exposed fetuses, whereas regulatory T cell (Treg) frequency decreased. These changes persisted for at least 48 h. Notably, Th17 cytokines were predominantly expressed by FOXP3+CD4+ T cells and not by their FOXP3− counterparts. Bifunctional IL-17+FOXP3+ exhibited a phenotype of inflammatory Tregs (RORcHigh/+, HeliosLow/−, IL-2+, IFN-γ+, and IL-8+) compared with typical FOXP3+ cells. Diminished splenic Treg frequency in LPS-exposed fetuses was associated with inadequate Treg generation in the thymus. Mechanistically, the emergence of inflammatory Tregs was largely dependent on IL-1 signaling. However, blockage of IL-1R signaling did not abolish the deleterious effects of LPS on Treg frequency in the thymus or spleen. Collectively, we demonstrate that a prenatal inflammatory environment leads to inadequate Treg generation in the thymus with a switch of splenic Tregs toward an inflammatory phenotype. Both processes likely contribute to the pathogenesis of chorioamnionitis. Approaches to manipulate Treg numbers and function could thus be useful therapeutically to alleviate FIRS in preterm infants." @default.
- W2316242578 created "2016-06-24" @default.
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- W2316242578 creator A5070942272 @default.
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- W2316242578 date "2016-05-01" @default.
- W2316242578 modified "2023-10-16" @default.
- W2316242578 title "Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1–Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque" @default.
- W2316242578 cites W1008189539 @default.
- W2316242578 cites W1486013549 @default.
- W2316242578 cites W1487359806 @default.
- W2316242578 cites W1518238956 @default.
- W2316242578 cites W1537122411 @default.
- W2316242578 cites W1663740629 @default.
- W2316242578 cites W1888697012 @default.
- W2316242578 cites W1894160618 @default.
- W2316242578 cites W1965814262 @default.
- W2316242578 cites W1971205210 @default.
- W2316242578 cites W1974357322 @default.
- W2316242578 cites W1975036797 @default.
- W2316242578 cites W1979413706 @default.
- W2316242578 cites W1981102729 @default.
- W2316242578 cites W1982907176 @default.
- W2316242578 cites W1984718156 @default.
- W2316242578 cites W1985516890 @default.
- W2316242578 cites W1989123225 @default.
- W2316242578 cites W1989992359 @default.
- W2316242578 cites W1993292726 @default.
- W2316242578 cites W1995188134 @default.
- W2316242578 cites W1998674631 @default.
- W2316242578 cites W2001051250 @default.
- W2316242578 cites W2002591986 @default.
- W2316242578 cites W2005124071 @default.
- W2316242578 cites W2006500041 @default.
- W2316242578 cites W2007425253 @default.
- W2316242578 cites W2010519878 @default.
- W2316242578 cites W2011446655 @default.
- W2316242578 cites W2016577907 @default.
- W2316242578 cites W2021298976 @default.
- W2316242578 cites W2023769703 @default.
- W2316242578 cites W2025234168 @default.
- W2316242578 cites W2027809616 @default.
- W2316242578 cites W2031448039 @default.
- W2316242578 cites W2035111684 @default.
- W2316242578 cites W2039004226 @default.
- W2316242578 cites W2040051879 @default.
- W2316242578 cites W2041137717 @default.
- W2316242578 cites W2045802874 @default.
- W2316242578 cites W2047294637 @default.
- W2316242578 cites W2047906621 @default.
- W2316242578 cites W2049043858 @default.
- W2316242578 cites W2061555046 @default.
- W2316242578 cites W2066975561 @default.
- W2316242578 cites W2069097983 @default.
- W2316242578 cites W2077492907 @default.
- W2316242578 cites W2078098797 @default.
- W2316242578 cites W2078610922 @default.
- W2316242578 cites W2079772272 @default.
- W2316242578 cites W2083459951 @default.
- W2316242578 cites W2083563896 @default.
- W2316242578 cites W2085059541 @default.
- W2316242578 cites W2086132113 @default.
- W2316242578 cites W2086595653 @default.
- W2316242578 cites W2087210742 @default.
- W2316242578 cites W2089152824 @default.
- W2316242578 cites W2092975931 @default.
- W2316242578 cites W2095513470 @default.
- W2316242578 cites W2096695199 @default.
- W2316242578 cites W2099808663 @default.
- W2316242578 cites W2102806222 @default.
- W2316242578 cites W2104401957 @default.
- W2316242578 cites W2104826177 @default.
- W2316242578 cites W2107651654 @default.
- W2316242578 cites W2111329034 @default.
- W2316242578 cites W2116824693 @default.
- W2316242578 cites W2120010406 @default.
- W2316242578 cites W2129226802 @default.
- W2316242578 cites W2133737057 @default.
- W2316242578 cites W2134053452 @default.
- W2316242578 cites W2137416873 @default.
- W2316242578 cites W2142877732 @default.
- W2316242578 cites W2148600653 @default.
- W2316242578 cites W2148646685 @default.
- W2316242578 cites W2159587574 @default.
- W2316242578 cites W2161412050 @default.
- W2316242578 cites W2165932899 @default.
- W2316242578 cites W2191493147 @default.
- W2316242578 cites W2253802357 @default.
- W2316242578 cites W2326987869 @default.
- W2316242578 cites W2408404578 @default.
- W2316242578 cites W2410017695 @default.
- W2316242578 cites W4243140277 @default.
- W2316242578 doi "https://doi.org/10.4049/jimmunol.1502613" @default.
- W2316242578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4868637" @default.