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- W2316256054 abstract "Pirenoxine ophthalmic solution was developed based on the quinoid theory which is one of the theories for development mechanism of senile cataracts, and its usefulness for treatment of cataracts has been proved. Since pirenoxine is unstable in aqueous solution, conventional products are required the reconstitution procedure of tablet (or granule) with accompanied solvent before use. Therefore, there are some problems with respect to good patient's compliance. Under these circumstances, one bottle type and stable pirenoxine ophthalmic product has been desired. Our concepts for designing new pirenoxine ophthalmic product are as follows, (1) To be one bottle type product, (2) To stabilize pirenoxine in aqueous media for three years at room temperature, (3) To keep its bioequivalence to conventional products. Pirenoxine showed very low solubility in acidic aqueous solution and good stability in aqueous suspension (pH 3.4-4.0) for three years at room temperature in our study. On the other hand, pirenoxine showed good solubility in neutral aqueous solution. We applied these unique properties and developed a new pirenoxine ophthalmic product, Kary Uni® ophthalmic suspension. As no buffer agent is contained in Kary Uni® ophthalmic suspension, the pH of the solution is elevated to the physicological pH of tears immediately after instillation, and pirenoxine microparticles rapidly dissolve in tears. As a result, the bioequivalence to conventional products can be obtained. Kary Uni® is a one bottle type ophthalmic suspension in ready to use, without the reconstitution procedure required for conventional products and is especially evaluated as a new type DDS pharmaceutical product taking advantage of the transformation on the living environment of ocular surface." @default.
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- W2316256054 date "1999-01-01" @default.
- W2316256054 modified "2023-10-05" @default.
- W2316256054 title "Pharmaceutical design of Kary Uni® ophthalmic suspension" @default.
- W2316256054 doi "https://doi.org/10.2745/dds.14.480" @default.
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