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- W2316264960 abstract "Significant toxicities result from the use of MVAC (methotrexate, vinblastine, adriamycin, cisplatin) for advanced/ recurrent transitional cell carcinoma of the bladder (ARTCCB). An alternative regimen of 5-fluorouracil (5-FU) and cisplatin was evaluated by Southwest Oncology Group (SWOG). Thirty-eight patients with ARTCCB were treated with continuous infusion 5-FU 1,000 mg/m2/days 1-5 and cisplatin 100 mg/day 1, on a every-21-days schedule. There were two complete responses (CR) and eight partial responses (PR) among 36 eligible patients, for an overall response rate of 28% [95% confidence interval (CI) 14-45%]. Median duration of response was 6 months, and median duration of survival was 9 months. No toxic deaths occurred. Grade 4 leukopenia occurred in 5 patients. Other toxicities were mild. Only two documented infections occurred in 5 patients with neutropenia. The response rate of 28% is better than that achieved with cisplatin alone and not dissimilar to the range of response for MVAC. Toxicities were less and tolerable. This regimen will need further evaluation." @default.
- W2316264960 created "2016-06-24" @default.
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- W2316264960 date "1997-08-01" @default.
- W2316264960 modified "2023-09-23" @default.
- W2316264960 title "Continuous-Infusion 5-Fluorouracil and Cisplatin for Advanced/Recurrent Transitional Cell Cancer of the Bladder: A Southwest Oncology Group Trial" @default.
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- W2316264960 doi "https://doi.org/10.1097/00000421-199708000-00001" @default.
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