FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316279295> ?p ?o ?g. }

• W2316279295 endingPage "876" @default.
• W2316279295 startingPage "866" @default.
• W2316279295 abstract "Background: Despite numerous articles on the use of artificial nerve conduits, autologous nerve transplants remain the most effective for nerve repair. To improve this technique, the authors examined conduits containing gelatin hydrogel as a carrier enabling the sustained release of basic fibroblast growth factor (bFGF). Methods: To confirm sustained bFGF release in vivo, nerve-guide tubes containing iodine-125–labeled bFGF with or without gelatin hydrogel were implanted under the skin of mice, and the remaining radioactivity was measured. Next, a 15-mm segment of the sciatic nerve was resected and repaired with autologous nerve (group 1), a tube with gelatin hydrogel and bFGF (group 2), a tube with bFGF alone (group 3), or a tube only (group 4). Histologic and functional analyses were performed for 16 weeks after surgery. Results: The radioactivity from iodine-125–labeled bFGF incorporated into gelatin hydrogel decreased more slowly than iodine-125–labeled bFGF alone. Four weeks after surgery, significantly more regenerating axons were detected in group 2 than in groups 3 and 4, but the axonal density in group 2 was lower than in group 1. Similarly, the animals in group 2 showed significantly better motor performance than those in groups 3 and 4, but worse than those in group 1. The animals in groups 1 and 2 showed significantly better sensory recovery than those in groups 3 and 4. Conclusions: The nerve-guide tube containing gelatin hydrogel and bFGF promoted axonal regeneration after peripheral nerve injury, but not as well as autologous transplants. Understanding the limitations of this technique will facilitate its improvement for clinical applications." @default.
• W2316279295 created "2016-06-24" @default.
• W2316279295 creator A5006144232 @default.
• W2316279295 creator A5009341567 @default.
• W2316279295 creator A5012786453 @default.
• W2316279295 creator A5015095774 @default.
• W2316279295 creator A5024414432 @default.
• W2316279295 creator A5035479034 @default.
• W2316279295 creator A5055033211 @default.
• W2316279295 creator A5060520248 @default.
• W2316279295 creator A5066683987 @default.
• W2316279295 creator A5069716683 @default.
• W2316279295 date "2012-10-01" @default.
• W2316279295 modified "2023-09-24" @default.
• W2316279295 title "Sustained bFGF-Release Tubes for Peripheral Nerve Regeneration" @default.
• W2316279295 cites W1711522978 @default.
• W2316279295 cites W1967064653 @default.
• W2316279295 cites W1986168567 @default.
• W2316279295 cites W1986512571 @default.
• W2316279295 cites W1988269444 @default.
• W2316279295 cites W1988544634 @default.
• W2316279295 cites W1997549639 @default.
• W2316279295 cites W2009078332 @default.
• W2316279295 cites W2026709323 @default.
• W2316279295 cites W2049110630 @default.
• W2316279295 cites W2054118527 @default.
• W2316279295 cites W2054344839 @default.
• W2316279295 cites W2062371191 @default.
• W2316279295 cites W2063679966 @default.
• W2316279295 cites W2065762841 @default.
• W2316279295 cites W2086262298 @default.
• W2316279295 cites W2089909243 @default.
• W2316279295 cites W2089956752 @default.
• W2316279295 cites W2103351070 @default.
• W2316279295 cites W2140867988 @default.
• W2316279295 cites W2156229286 @default.
• W2316279295 cites W2329207906 @default.
• W2316279295 doi "https://doi.org/10.1097/prs.0b013e318262f36e" @default.
• W2316279295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23018697" @default.
• W2316279295 hasPublicationYear "2012" @default.
• W2316279295 type Work @default.
• W2316279295 sameAs 2316279295 @default.
• W2316279295 citedByCount "17" @default.
• W2316279295 countsByYear W23162792952013 @default.
• W2316279295 countsByYear W23162792952014 @default.
• W2316279295 countsByYear W23162792952015 @default.
• W2316279295 countsByYear W23162792952016 @default.
• W2316279295 countsByYear W23162792952017 @default.
• W2316279295 countsByYear W23162792952019 @default.
• W2316279295 countsByYear W23162792952021 @default.
• W2316279295 countsByYear W23162792952022 @default.
• W2316279295 countsByYear W23162792952023 @default.
• W2316279295 crossrefType "journal-article" @default.
• W2316279295 hasAuthorship W2316279295A5006144232 @default.
• W2316279295 hasAuthorship W2316279295A5009341567 @default.
• W2316279295 hasAuthorship W2316279295A5012786453 @default.
• W2316279295 hasAuthorship W2316279295A5015095774 @default.
• W2316279295 hasAuthorship W2316279295A5024414432 @default.
• W2316279295 hasAuthorship W2316279295A5035479034 @default.
• W2316279295 hasAuthorship W2316279295A5055033211 @default.
• W2316279295 hasAuthorship W2316279295A5060520248 @default.
• W2316279295 hasAuthorship W2316279295A5066683987 @default.
• W2316279295 hasAuthorship W2316279295A5069716683 @default.
• W2316279295 hasConcept C105702510 @default.
• W2316279295 hasConcept C126322002 @default.
• W2316279295 hasConcept C136940099 @default.
• W2316279295 hasConcept C141071460 @default.
• W2316279295 hasConcept C150903083 @default.
• W2316279295 hasConcept C170493617 @default.
• W2316279295 hasConcept C171056886 @default.
• W2316279295 hasConcept C185592680 @default.
• W2316279295 hasConcept C207001950 @default.
• W2316279295 hasConcept C2775960820 @default.
• W2316279295 hasConcept C2777587049 @default.
• W2316279295 hasConcept C2778823387 @default.
• W2316279295 hasConcept C2781149210 @default.
• W2316279295 hasConcept C3018498973 @default.
• W2316279295 hasConcept C42219234 @default.
• W2316279295 hasConcept C55493867 @default.
• W2316279295 hasConcept C71924100 @default.
• W2316279295 hasConcept C86803240 @default.
• W2316279295 hasConcept C95444343 @default.
• W2316279295 hasConceptScore W2316279295C105702510 @default.
• W2316279295 hasConceptScore W2316279295C126322002 @default.
• W2316279295 hasConceptScore W2316279295C136940099 @default.
• W2316279295 hasConceptScore W2316279295C141071460 @default.
• W2316279295 hasConceptScore W2316279295C150903083 @default.
• W2316279295 hasConceptScore W2316279295C170493617 @default.
• W2316279295 hasConceptScore W2316279295C171056886 @default.
• W2316279295 hasConceptScore W2316279295C185592680 @default.
• W2316279295 hasConceptScore W2316279295C207001950 @default.
• W2316279295 hasConceptScore W2316279295C2775960820 @default.
• W2316279295 hasConceptScore W2316279295C2777587049 @default.
• W2316279295 hasConceptScore W2316279295C2778823387 @default.
• W2316279295 hasConceptScore W2316279295C2781149210 @default.
• W2316279295 hasConceptScore W2316279295C3018498973 @default.
• W2316279295 hasConceptScore W2316279295C42219234 @default.
• W2316279295 hasConceptScore W2316279295C55493867 @default.

• next