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• W2316285005 startingPage "1067" @default.
• W2316285005 abstract "Cephalostatin 1 (1) has proved to be a remarkably potent cancer cell growth inhibitor. Since this steroidal alkaloid constituent of the marine worm Cephalodiscus gilchristi possesses a complex structure, providing preclinical supplies by total synthesis continues to be challenging. Therefore, syntheses of less complex structural modifications of this important pyrazine have also received substantial attention. Herein are summarized the synthesis of [5.5]spiroketal 5, a simplified right-side steroidal unit of 1, in seven steps from hecogenin acetate (11) with an overall yield of 4.6%. Consistent with other SAR studies, such reduction in structural complexity compared to 1 led to loss of cancer cell growth inhibitory activity against the P388 lymphocytic leukemia cell line." @default.
• W2316285005 created "2016-06-24" @default.
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• W2316285005 date "2015-04-27" @default.
• W2316285005 modified "2023-10-16" @default.
• W2316285005 title "The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11" @default.
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• W2316285005 doi "https://doi.org/10.1021/np501033u" @default.
• W2316285005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25915559" @default.
• W2316285005 hasPublicationYear "2015" @default.
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