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• W2316305032 endingPage "3317" @default.
• W2316305032 startingPage "3301" @default.
• W2316305032 abstract "In this work, we investigated the relationship between various intermolecular hydrogen-bonding (H-bonding) interactions and the miscibility of the model hydrophobic drug naproxen with the hydrophilic polymer polyvinylpyrrolidone (PVP) across an entire composition range of solid dispersions prepared by quasi-equilibrium film casting and nonequilibrium melt quench cooling. The binary phase behavior in solid dispersions exhibited substantial processing method dependence. The solid state solubility of crystalline naproxen in PVP to form amorphous solid dispersions was 35% and 70% w/w naproxen in solution-cast films and quench-cooled films, respectively. However, the presence of a single mixed phase glass transition indicated the amorphous miscibility to be 20% w/w naproxen for the films, beyond which amorphous–amorphous and/or crystalline phase separations were apparent. This was further supported by the solution state interactions data such as PVP globular size distribution and solution infrared spectral profiles. The borderline melt composition showed cooling rate dependence of amorphization. The glass transition and melting point depression profiles of the system were treated with the analytical expressions based on Flory–Huggins mixing theory to interpolate the equilibrium solid solubility. FTIR analysis and subsequent spectral deconvolution revealed composition and miscibility dependent variations in the strength of drug–polymer intermolecular H-bonding. Two types of H-bonded populations were evidenced from 25% w/w and 35% w/w naproxen in solution-cast films and quench-cooled films, respectively, with the higher fraction of strongly H-bonded population in the drug rich domains of phase separated amorphous film compositions and highly drug loaded amorphous quench-cooled dispersions." @default.
• W2316305032 created "2016-06-24" @default.
• W2316305032 creator A5018182671 @default.
• W2316305032 creator A5040003588 @default.
• W2316305032 creator A5082281570 @default.
• W2316305032 date "2012-10-15" @default.
• W2316305032 modified "2023-09-23" @default.
• W2316305032 title "Relating Hydrogen-Bonding Interactions with the Phase Behavior of Naproxen/PVP K 25 Solid Dispersions: Evaluation of Solution-Cast and Quench-Cooled Films" @default.
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• W2316305032 doi "https://doi.org/10.1021/mp3003495" @default.
• W2316305032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23009610" @default.
• W2316305032 hasPublicationYear "2012" @default.
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