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• W2316307301 abstract "Event Abstract Back to Event In Vivo effects of 18α-Glycyrrhetinic acid on phenotypic and functional properties of dendritic cells Salimeh Ebrahimnezhad Darzi1, Zahra Amirghofran2, Narges Bordbar2 and Mohammad H. Karimi1* 1 Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Iran 2 Immunology Department and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical sciences, Shiraz, Iran, Iran Dendritic cells (DCs) play a central role in the initiation of immune responses. The compounds which have the ability to induce immunomodulatory effects on DCs may be employed for the treatment of autoimmune diseases and allograft rejection. The aim of this study was to investigate the in-vivo effects of 18α-Glycyrrhetinic acid on DCs. 10 milligram/kg 18α-Glycyrrhetinic acid was injected intra-peritoneally into BALB/c mice every other day within 4 weeks, and splenic DCs were isolated using nycodenz. The phenotypic and functional properties of DCs were studied by flow cytometry and mixed lymphocyte reaction (MLR), respectively. In addition, the percentage of Tregs was compared in both groups and the level of IL-4 and IFN-γ in MLR supernatant and mice serum were measured by ELISA kits. Determination of TLR mRNA expression level using real time PCR, other accessory of this study, will be done. As a result, flow cytometry analysis showed expression of CD40 (P<0.0250) and MHC II (P<0.0048), as maturation markers and costimulatory molecules were significantly decreased. Also, expression of CD86 was not changed in test group compared to control group. The percentage of Tregs in control (2.350±0.8227) and test (1.276±0.4477) groups was not statically significant. The level of IL-4 and IFN-γ was not different in MLR supernatant and serum of both groups. Allogeneic T cell stimulation in MLR was also significantly inhibited in comparison with the control groups (p<0.05). Our data indicate that in-vivo 18α-Glycyrrhetinic acid administration inhibits maturation and activation of DCs in the same manner as in-vitro conditions. Keywords: 18α-Glycyrrhetinic acid, Dendritic cells (DCs), Immunomodulatory effect, costimulatory molecules, Invivo study Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Ebrahimnezhad Darzi S, Amirghofran Z, Bordbar N and Karimi MH (2013). In Vivo effects of 18α-Glycyrrhetinic acid on phenotypic and functional properties of dendritic cells. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00038 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Mohammad H Karimi, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Shiraz, Iran, karimi70@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Salimeh Ebrahimnezhad Darzi Zahra Amirghofran Narges Bordbar Mohammad H Karimi Google Salimeh Ebrahimnezhad Darzi Zahra Amirghofran Narges Bordbar Mohammad H Karimi Google Scholar Salimeh Ebrahimnezhad Darzi Zahra Amirghofran Narges Bordbar Mohammad H Karimi PubMed Salimeh Ebrahimnezhad Darzi Zahra Amirghofran Narges Bordbar Mohammad H Karimi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2316307301 title "In Vivo effects of 18a-Glycyrrhetinic acid on phenotypic and functional properties of dendritic cells" @default.
• W2316307301 doi "https://doi.org/10.3389/conf.fimmu.2013.02.00038" @default.
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