Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316315025> ?p ?o ?g. }
- W2316315025 endingPage "123" @default.
- W2316315025 startingPage "101" @default.
- W2316315025 abstract "This writing proposes an overview of chemical processes of isomerisation involving conformations and configurational isomers. Molecular structure is depicted as consisting in A) core features; and B) fluctuating properties. To avoid confusion and misuses in terminology, attention is paid to IUPAC recommendations and definitions, beginning with a focus on conformers versus conformations. Two sections consider rotations, the behaviour of exocyclic single bonds being kept separate from that of endocyclic single bonds. Processes of pyramidal inversions are discussed next, alone and combined with rotations. Given its sometimes unsuspected occurrence in some drug molecules, stereolability at tetracoordinated carbon centres receives particular attention. Stereolabile and stereostable nitrogen-containing groups come next, with a focus on the simultaneous contributions of inversion and rotation as occurring for example in the conformational reversal of saturated aza-heterocycles. The last type of isomerisation to be examined involves complex heterocyclic systems of medicinal relevance. The conclusion points to the mechanistic variety of stereoisomerisation processes, to a continuum in their energy barriers, to their relevance in all fields of stereochemistry, and to the need for junior medicinal chemists to be adequately trained in stereochemistry." @default.
- W2316315025 created "2016-06-24" @default.
- W2316315025 creator A5004734394 @default.
- W2316315025 creator A5028843194 @default.
- W2316315025 creator A5080796605 @default.
- W2316315025 date "2016-06-01" @default.
- W2316315025 modified "2023-10-10" @default.
- W2316315025 title "Mechanisms and pharmaceutical consequences of processes of stereoisomerisation — A didactic excursion" @default.
- W2316315025 cites W1150055 @default.
- W2316315025 cites W1194529981 @default.
- W2316315025 cites W1485975267 @default.
- W2316315025 cites W1503908162 @default.
- W2316315025 cites W1509739650 @default.
- W2316315025 cites W1514484365 @default.
- W2316315025 cites W1542342885 @default.
- W2316315025 cites W1548153198 @default.
- W2316315025 cites W1557326050 @default.
- W2316315025 cites W1565036411 @default.
- W2316315025 cites W1574356778 @default.
- W2316315025 cites W1585838210 @default.
- W2316315025 cites W1602455494 @default.
- W2316315025 cites W1602871273 @default.
- W2316315025 cites W1608525014 @default.
- W2316315025 cites W1964028753 @default.
- W2316315025 cites W1964100147 @default.
- W2316315025 cites W1964863988 @default.
- W2316315025 cites W1974249292 @default.
- W2316315025 cites W1975729750 @default.
- W2316315025 cites W1980040349 @default.
- W2316315025 cites W1984071215 @default.
- W2316315025 cites W1986253930 @default.
- W2316315025 cites W1988944195 @default.
- W2316315025 cites W1989345949 @default.
- W2316315025 cites W1989415923 @default.
- W2316315025 cites W1991176077 @default.
- W2316315025 cites W1992385346 @default.
- W2316315025 cites W1994799683 @default.
- W2316315025 cites W1998151458 @default.
- W2316315025 cites W1998876013 @default.
- W2316315025 cites W2004686031 @default.
- W2316315025 cites W2006096418 @default.
- W2316315025 cites W2006902983 @default.
- W2316315025 cites W2009077552 @default.
- W2316315025 cites W2009828525 @default.
- W2316315025 cites W2010147050 @default.
- W2316315025 cites W2011590223 @default.
- W2316315025 cites W2013023166 @default.
- W2316315025 cites W2013299243 @default.
- W2316315025 cites W2020069533 @default.
- W2316315025 cites W2022769623 @default.
- W2316315025 cites W2022950330 @default.
- W2316315025 cites W2024362383 @default.
- W2316315025 cites W2024427405 @default.
- W2316315025 cites W2032084435 @default.
- W2316315025 cites W2032521019 @default.
- W2316315025 cites W2033571142 @default.
- W2316315025 cites W2036203356 @default.
- W2316315025 cites W2036272063 @default.
- W2316315025 cites W2043775194 @default.
- W2316315025 cites W2044724136 @default.
- W2316315025 cites W2045625682 @default.
- W2316315025 cites W2050951947 @default.
- W2316315025 cites W2052800549 @default.
- W2316315025 cites W2055612001 @default.
- W2316315025 cites W2055629831 @default.
- W2316315025 cites W2057991237 @default.
- W2316315025 cites W2060977223 @default.
- W2316315025 cites W2068351778 @default.
- W2316315025 cites W2069825812 @default.
- W2316315025 cites W2070714759 @default.
- W2316315025 cites W2073243303 @default.
- W2316315025 cites W2074803089 @default.
- W2316315025 cites W2074808135 @default.
- W2316315025 cites W2083868756 @default.
- W2316315025 cites W2085687372 @default.
- W2316315025 cites W2085704017 @default.
- W2316315025 cites W2094595706 @default.
- W2316315025 cites W2108327555 @default.
- W2316315025 cites W2110197385 @default.
- W2316315025 cites W2112300060 @default.
- W2316315025 cites W2118312292 @default.
- W2316315025 cites W2120637480 @default.
- W2316315025 cites W2122839730 @default.
- W2316315025 cites W2127495700 @default.
- W2316315025 cites W2130826801 @default.
- W2316315025 cites W2132289924 @default.
- W2316315025 cites W2134680396 @default.
- W2316315025 cites W2135953480 @default.
- W2316315025 cites W2138168761 @default.
- W2316315025 cites W2141327626 @default.
- W2316315025 cites W2142690255 @default.
- W2316315025 cites W2147445502 @default.
- W2316315025 cites W2149037335 @default.
- W2316315025 cites W2164839496 @default.
- W2316315025 cites W2164872044 @default.
- W2316315025 cites W2167205313 @default.
- W2316315025 cites W2167519528 @default.
- W2316315025 cites W2170802113 @default.