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• W2316333493 abstract "Gold nanoparticles (GNPs) are widely used in many fields due to their compatibility with various biosystems and their ability to be easily functionalized with biomolecules. However, current citrate-reduced GNPs are prone to aggregate and unstable at high ionic strength solution, which greatly limits their applications. Thus, new preparation methods of the GNPs, which can maintain the stability under the extreme conditions, are still urgently needed. Here, we describe a new GNP synthesis strategy by using trisodium citrate to reduce hydrogen tetrachloroaurate (III) (HAuCl4) in the presence of single-strand DNA (ssDNA) at 37 °C. Under the assistance of the ssDNA, the GNPs can be prepared at physiological temperature and still maintain the uniform shape and dispersity. More importantly, the stability of the GNPs against salt-induced aggregation was improved greatly. With their high stability and in situ functionalized ssDNA, these GNPs have great potential in physiological systems and could be used for nanomedicine, nanoapparatus, and other applications." @default.
• W2316333493 created "2016-06-24" @default.
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• W2316333493 date "2011-02-10" @default.
• W2316333493 modified "2023-09-25" @default.
• W2316333493 title "New Synthesis Strategy for DNA Functional Gold Nanoparticles" @default.
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• W2316333493 doi "https://doi.org/10.1021/jp109688q" @default.
• W2316333493 hasPublicationYear "2011" @default.
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