Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316349178> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2316349178 endingPage "1997" @default.
- W2316349178 startingPage "1953" @default.
- W2316349178 abstract "Various delivery strategies, involving siRNA as a therapeutic tool for gene silencing, have been highlighted through several investigations all over the world. One such medical target, where the siRNA-based therapies have been immensely explored and have met with considerable success, is the area of pulmonary disorders. Lung diseases have presented themselves as attractive targets for studying siRNA-mediated cures due to their widespread persistence and lethality. Another interesting feature in this case is that the lung is accessible to therapeutic agents via multiple administration routes including the nasal, oral and intravenous routes. Recent advances in pulmonary delivery highlight the exploitation of all these routes for administration of siRNA-based therapies, particularly by employing non-viral carriers like nanoparticles. Through this manuscript we aim to provide a comprehensive overview of the most important and the latest developments in non-viral siRNA delivery for lung diseases. We have focused our discussion on the diverse systems, which have been investigated for a plethora of pulmonary disorders, ranging from inflammatory conditions like asthma and COPD, to infectious diseases like tuberculosis, and to lung cancer. An overview of the preclinical and clinical investigations conducted in this area has also been presented to the readers. While a variety of these systems have been found to be promising in pre-clinical studies, their successful transition as therapeutics will ultimately depend upon their clinical safety and efficacy, as well as the specificity of the carriers and methods employed for their administration." @default.
- W2316349178 created "2016-06-24" @default.
- W2316349178 creator A5009078440 @default.
- W2316349178 creator A5053451333 @default.
- W2316349178 creator A5058791710 @default.
- W2316349178 creator A5064602598 @default.
- W2316349178 creator A5072290253 @default.
- W2316349178 date "2014-09-01" @default.
- W2316349178 modified "2023-10-17" @default.
- W2316349178 title "siRNA-Based Therapies for Pulmonary Diseases" @default.
- W2316349178 doi "https://doi.org/10.1166/jbn.2014.1928" @default.
- W2316349178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25992446" @default.
- W2316349178 hasPublicationYear "2014" @default.
- W2316349178 type Work @default.
- W2316349178 sameAs 2316349178 @default.
- W2316349178 citedByCount "17" @default.
- W2316349178 countsByYear W23163491782015 @default.
- W2316349178 countsByYear W23163491782016 @default.
- W2316349178 countsByYear W23163491782017 @default.
- W2316349178 countsByYear W23163491782018 @default.
- W2316349178 countsByYear W23163491782019 @default.
- W2316349178 countsByYear W23163491782020 @default.
- W2316349178 countsByYear W23163491782021 @default.
- W2316349178 countsByYear W23163491782022 @default.
- W2316349178 countsByYear W23163491782023 @default.
- W2316349178 crossrefType "journal-article" @default.
- W2316349178 hasAuthorship W2316349178A5009078440 @default.
- W2316349178 hasAuthorship W2316349178A5053451333 @default.
- W2316349178 hasAuthorship W2316349178A5058791710 @default.
- W2316349178 hasAuthorship W2316349178A5064602598 @default.
- W2316349178 hasAuthorship W2316349178A5072290253 @default.
- W2316349178 hasConcept C104317684 @default.
- W2316349178 hasConcept C119056186 @default.
- W2316349178 hasConcept C126322002 @default.
- W2316349178 hasConcept C142724271 @default.
- W2316349178 hasConcept C177713679 @default.
- W2316349178 hasConcept C203014093 @default.
- W2316349178 hasConcept C2776042228 @default.
- W2316349178 hasConcept C2776256026 @default.
- W2316349178 hasConcept C2776780178 @default.
- W2316349178 hasConcept C55493867 @default.
- W2316349178 hasConcept C60644358 @default.
- W2316349178 hasConcept C71924100 @default.
- W2316349178 hasConcept C86803240 @default.
- W2316349178 hasConceptScore W2316349178C104317684 @default.
- W2316349178 hasConceptScore W2316349178C119056186 @default.
- W2316349178 hasConceptScore W2316349178C126322002 @default.
- W2316349178 hasConceptScore W2316349178C142724271 @default.
- W2316349178 hasConceptScore W2316349178C177713679 @default.
- W2316349178 hasConceptScore W2316349178C203014093 @default.
- W2316349178 hasConceptScore W2316349178C2776042228 @default.
- W2316349178 hasConceptScore W2316349178C2776256026 @default.
- W2316349178 hasConceptScore W2316349178C2776780178 @default.
- W2316349178 hasConceptScore W2316349178C55493867 @default.
- W2316349178 hasConceptScore W2316349178C60644358 @default.
- W2316349178 hasConceptScore W2316349178C71924100 @default.
- W2316349178 hasConceptScore W2316349178C86803240 @default.
- W2316349178 hasIssue "9" @default.
- W2316349178 hasLocation W23163491781 @default.
- W2316349178 hasLocation W23163491782 @default.
- W2316349178 hasOpenAccess W2316349178 @default.
- W2316349178 hasPrimaryLocation W23163491781 @default.
- W2316349178 hasRelatedWork W1485073643 @default.
- W2316349178 hasRelatedWork W2039776892 @default.
- W2316349178 hasRelatedWork W2168449172 @default.
- W2316349178 hasRelatedWork W2362299873 @default.
- W2316349178 hasRelatedWork W2372071230 @default.
- W2316349178 hasRelatedWork W2544769471 @default.
- W2316349178 hasRelatedWork W3029719335 @default.
- W2316349178 hasRelatedWork W4255825817 @default.
- W2316349178 hasRelatedWork W4322724676 @default.
- W2316349178 hasRelatedWork W1783504628 @default.
- W2316349178 hasVolume "10" @default.
- W2316349178 isParatext "false" @default.
- W2316349178 isRetracted "false" @default.
- W2316349178 magId "2316349178" @default.
- W2316349178 workType "article" @default.