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- W2316368713 startingPage "107" @default.
- W2316368713 abstract "1．ラットにHY-770(50mg/kg)を経口投与した時，24時間までの尿における未変化体は0.89%に過ぎず，一方，多くの代謝物が見られるので，HY-770は代謝を受けやすい化合物であることがわかった．2．主な代謝物6種の構造が決定され，それらは(I)ベンゼソ環側鎖エチル基の酸化，(II)ケトン基の還元，(III)ピロリジン基の開裂の3つの代謝経路により生成していると考えられる．3．排泄率の高い代謝物は，いずれも上記の(I)ベンゼン環側鎖エチル基の酸化による生成物で，ラットにおいては，この部位の変化が主代謝経路であると考えられる．" @default.
- W2316368713 created "2016-06-24" @default.
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- W2316368713 date "1989-01-01" @default.
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- W2316368713 title "Metabolic fate of HY-770 (III). Metabolism in rats." @default.
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- W2316368713 doi "https://doi.org/10.2133/dmpk.4.107" @default.
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