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• W2316383690 abstract "Mechanical preconditioning and mechanical properties of tissue engineered constructs are essential for their capability to regenerate damaged tissues. To online monitor the mechanical properties a hydrostatic pressure bioreactor was coupled with optical coherence tomography into a new image modality termed hydrostatic pressure optical coherence elastography (HP-OCE). HP-OCE was utilised to assess the properties of three-dimensional (3D) tissue constructs while being physically stimulated within the hydrostatic force bioreactor. Hydrogels have been infiltrated into porous rapid prototyped or salt-leached scaffolds to mimic heterogeneous mechanical properties of cell-seeded constructs. Variations of mechanical properties in the solid scaffolds and agarose gels with different gel concentrations as well as the presences of cells have been clearly delineated by HP-OCE. Results indicate that HP-OCE allows contactless real-time non-invasive monitoring of the mechanical properties of tissue constructs and the effect of physical stimulation on cellular activities." @default.
• W2316383690 created "2016-06-24" @default.
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• W2316383690 date "2016-03-09" @default.
• W2316383690 modified "2023-09-23" @default.
• W2316383690 title "Online monitoring of mechanical properties of three-dimensional tissue engineered constructs for quality assessment" @default.
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• W2316383690 doi "https://doi.org/10.1117/12.2212320" @default.
• W2316383690 hasPublicationYear "2016" @default.
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