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• W2316384098 abstract "The establishment of protocols to differentiate human pluripotent stem cells (hPSCs) including embryonic (ESC) and induced pluripotent (iPSC) stem cells into functional hepatocyte-like cells (HLCs) creates new opportunities to study liver metabolism, genetic diseases and infection of hepatotropic viruses (hepatitis B and C viruses) in the context of specific genetic background. While supporting efficient differentiation to HLCs, the published protocols are limited in terms of differentiation into fully mature hepatocytes and in a smaller-well format. This limitation handicaps the application of these cells to high-throughput assays. Here we describe a protocol allowing efficient and consistent hepatic differentiation of hPSCs in 384-well plates into functional hepatocyte-like cells, which remain differentiated for more than 3 weeks. This protocol affords the unique opportunity to miniaturize the hPSC-based differentiation technology and facilitates screening for molecules in modulating liver differentiation, metabolism, genetic network, and response to infection or other external stimuli." @default.
• W2316384098 created "2016-06-24" @default.
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• W2316384098 date "2016-05-01" @default.
• W2316384098 modified "2023-10-16" @default.
• W2316384098 title "Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen" @default.
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• W2316384098 doi "https://doi.org/10.1016/j.scr.2016.03.009" @default.
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