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- W2316390149 abstract "<h3>Objective</h3> To investigate whether ramipril, valsartan and anlodipine play a role in expression of transient receptor potential canonical 3 and 6 channel (TRPC3, TRPC6) at the aorta in spontaneously hypertensive rats (SHR). <h3>Methods</h3> SHRs were randomly divided into four groups: ramipril group (n=6), valsartan group (n=6), amlodipine group (n=6) and no drug group (n=6). Wistar-Kyoto (WKY) rats were used as control group (n=6). After treated for 4 weeks, the rats were examined for blood pressure, the mRNA expression of TRPC3 and TRPC6 were determined by RT-PCR and the protein level of TRPC3 and TRPC6 by immunohistochemistry and Western Blot. <h3>Results</h3> TRPC3 and TRPC6 increased in aorta from SHR compared with normotensive WKY rats (p<0.05). In drug groups, the systemic blood pressure and the mRNA and protein expression of TRPC3 decreased (p<0.05), but the expression of TRPC6 had no change. <h3>Conclusion</h3> In SHR rats, increased expressions of TRPC3, TRPC6 channels mRNA and protein in the vasculature may play a role in elevated blood pressure. Ramipril, valsartan and anlodipine possibly reduced blood pressure partly by inhibition of TRPC3 expression." @default.
- W2316390149 created "2016-06-24" @default.
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- W2316390149 date "2011-10-01" @default.
- W2316390149 modified "2023-09-24" @default.
- W2316390149 title "The effect of antihypertensive on the expression of TRPC3 and TRPC6 in the aorta in spontaneously hypertensive rats" @default.
- W2316390149 doi "https://doi.org/10.1136/heartjnl-2011-300867.14" @default.
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