Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316395586> ?p ?o ?g. }
- W2316395586 endingPage "76" @default.
- W2316395586 startingPage "67" @default.
- W2316395586 abstract "Ageing is characterised by progressive deterioration of physiological systems and the loss of skeletal muscle mass is one of the most recognisable, leading to muscle weakness and mobility impairments. This review highlights interactions between the immune system and skeletal muscle stem cells (widely termed satellite cells or myoblasts) to influence satellite cell behaviour during muscle regeneration after injury, and outlines deficits associated with ageing. Resident neutrophils and macrophages in skeletal muscle become activated when muscle fibres are damaged via stimuli (e.g. contusions, strains, avulsions, hyperextensions, ruptures) and release high concentrations of cytokines, chemokines and growth factors into the microenvironment. These localised responses serve to attract additional immune cells which can reach in excess of 1 × 105 immune cell/mm3 of skeletal muscle in order to orchestrate the repair process. T-cells have a delayed response, reaching peak activation roughly 4 days after the initial damage. The cytokines and growth factors released by activated T-cells play a key role in muscle satellite cell proliferation and migration, although the precise mechanisms of these interactions remain unclear. T-cells in older people display limited ability to activate satellite cell proliferation and migration which is likely to contribute to insufficient muscle repair and, consequently, muscle wasting and weakness. If the factors released by T-cells to activate satellite cells can be identified, it may be possible to develop therapeutic agents to enhance muscle regeneration and reduce the impact of muscle wasting during ageing and disease." @default.
- W2316395586 created "2016-06-24" @default.
- W2316395586 creator A5040162501 @default.
- W2316395586 creator A5044621157 @default.
- W2316395586 creator A5053848570 @default.
- W2316395586 creator A5059156893 @default.
- W2316395586 creator A5091373218 @default.
- W2316395586 date "2016-05-01" @default.
- W2316395586 modified "2023-10-11" @default.
- W2316395586 title "Regenerative function of immune system: Modulation of muscle stem cells" @default.
- W2316395586 cites W139379903 @default.
- W2316395586 cites W1487754058 @default.
- W2316395586 cites W1500593540 @default.
- W2316395586 cites W1507043810 @default.
- W2316395586 cites W1511347124 @default.
- W2316395586 cites W1538447709 @default.
- W2316395586 cites W1548584275 @default.
- W2316395586 cites W1552699877 @default.
- W2316395586 cites W1572327103 @default.
- W2316395586 cites W1647542124 @default.
- W2316395586 cites W1870980090 @default.
- W2316395586 cites W1883467562 @default.
- W2316395586 cites W1932610186 @default.
- W2316395586 cites W1962551563 @default.
- W2316395586 cites W1967544564 @default.
- W2316395586 cites W1967782952 @default.
- W2316395586 cites W1969630360 @default.
- W2316395586 cites W1971173086 @default.
- W2316395586 cites W1977745244 @default.
- W2316395586 cites W1979173328 @default.
- W2316395586 cites W1980630637 @default.
- W2316395586 cites W1982174586 @default.
- W2316395586 cites W1982436378 @default.
- W2316395586 cites W1987413475 @default.
- W2316395586 cites W1988393390 @default.
- W2316395586 cites W1992586784 @default.
- W2316395586 cites W1994129658 @default.
- W2316395586 cites W1995381409 @default.
- W2316395586 cites W1997149085 @default.
- W2316395586 cites W1998004606 @default.
- W2316395586 cites W1998118119 @default.
- W2316395586 cites W2000119824 @default.
- W2316395586 cites W2000814289 @default.
- W2316395586 cites W2001441616 @default.
- W2316395586 cites W2002593980 @default.
- W2316395586 cites W2013306406 @default.
- W2316395586 cites W2017075649 @default.
- W2316395586 cites W2018448066 @default.
- W2316395586 cites W2022487205 @default.
- W2316395586 cites W2025347796 @default.
- W2316395586 cites W2026578487 @default.
- W2316395586 cites W2026942934 @default.
- W2316395586 cites W2031145230 @default.
- W2316395586 cites W2032983525 @default.
- W2316395586 cites W2033127864 @default.
- W2316395586 cites W2037716289 @default.
- W2316395586 cites W2038894878 @default.
- W2316395586 cites W2043123806 @default.
- W2316395586 cites W2045836911 @default.
- W2316395586 cites W2046185880 @default.
- W2316395586 cites W2047076065 @default.
- W2316395586 cites W2051013988 @default.
- W2316395586 cites W2057070304 @default.
- W2316395586 cites W2060890640 @default.
- W2316395586 cites W2065577291 @default.
- W2316395586 cites W2072493014 @default.
- W2316395586 cites W2076284651 @default.
- W2316395586 cites W2081067390 @default.
- W2316395586 cites W2088148916 @default.
- W2316395586 cites W2093705034 @default.
- W2316395586 cites W2096258042 @default.
- W2316395586 cites W2096302008 @default.
- W2316395586 cites W2097173670 @default.
- W2316395586 cites W2097304128 @default.
- W2316395586 cites W2100722902 @default.
- W2316395586 cites W2100814682 @default.
- W2316395586 cites W2102902846 @default.
- W2316395586 cites W2108723188 @default.
- W2316395586 cites W2109381162 @default.
- W2316395586 cites W2109534726 @default.
- W2316395586 cites W2110077620 @default.
- W2316395586 cites W2114596120 @default.
- W2316395586 cites W2115150337 @default.
- W2316395586 cites W2118424059 @default.
- W2316395586 cites W2123245071 @default.
- W2316395586 cites W2124672774 @default.
- W2316395586 cites W2126792732 @default.
- W2316395586 cites W2129155846 @default.
- W2316395586 cites W2129976097 @default.
- W2316395586 cites W2130594874 @default.
- W2316395586 cites W2131230765 @default.
- W2316395586 cites W2131585324 @default.
- W2316395586 cites W2132035753 @default.
- W2316395586 cites W2132099317 @default.
- W2316395586 cites W2133682828 @default.
- W2316395586 cites W2135626241 @default.
- W2316395586 cites W2138514622 @default.
- W2316395586 cites W2140004478 @default.