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- W2316396366 abstract "Current guidelines recommend that patients undergoing coronary stenting receive dual-antiplatelet therapy to prevent acute stent thrombosis. There is limited data on platelet inhibition in pts presenting with cardiac arrest who require both acute coronary stenting and therapeutic hypothermia (TH). We sought to determine the extent of platelet inhibition in pts requiring TH who were treated with clopidogrel. We prospectively recruited patients who presented with a cardiac arrest who required TH and acute coronary stenting. The loading dose of clopidogrel was 600mg followed by a maintenance dose of 75mg daily administered via a nasogastric tube. Platelet function was tested at baseline, and at 4, 8, 24, 48, 72, 96 and 120 hrs from the loading dose of clopidogrel. Platelet activity was analyzed with the VerifyNow point-of-care rapid platelet function analyzer. The primary endpoint was the extent of platelet inhibition as a function of time during the first 6 days after the loading dose of clopidogrel. We evaluated 8 consecutive patients who received coronary stents and subsequently required TH. All patients received clopidogrel to prevent stent closure. The results of the platelet testing are depicted in the figure below. During the 24 hour period of TH, there was minimal response to clopidogrel as 7 out of 8 pts had 0% of platelet inhibition and 1 patient had marginal response of 7%. Platelet inhibition became apparent during the re-warming phase but appeared to be relatively delayed. In this pilot trial, we found that platelet inhibition with clopidogrel was minimal during the period of TH. These results raise concerns regarding the potential risks of stent thrombosis in pts receiving stents and managed with TH." @default.
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- W2316396366 date "2012-09-01" @default.
- W2316396366 modified "2023-09-25" @default.
- W2316396366 title "474 Markedly Reduced Platelet Inhibition With Clopidogrel Given to Patients Undergoing Therapeutic Hypothermia Post Cardiac Arrest" @default.
- W2316396366 doi "https://doi.org/10.1016/j.cjca.2012.07.435" @default.
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