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• W2316397705 endingPage "263" @default.
• W2316397705 startingPage "253" @default.
• W2316397705 abstract "Improving child cognition in impoverished countries is a public health priority. Yet, biological pathways and associated biomarkers of impaired cognition remain poorly understood and largely unknown, respectively. This study aimed to explore and quantify associations between functional plasma protein biomarkers and childhood intellectual test performance. We applied proteomics to quantify proteins in plasma samples of 249 rural Nepalese children, 6-8years of age who, 1year later at 7-9years of age, were administered the Universal Nonverbal Intelligence Test (UNIT). Among 751 plasma proteins quantified, 22 were associated with UNIT scores, passing a false discovery rate threshold of 5.0% (q<0.05). UNIT scores were higher by 2.3-9.2 points for every 50% increase in relative abundance of two insulin-like growth factor binding proteins (IGFBPs), six subclasses of apolipoprotein (Apo) and transthyretin, and lower by 4.0-15.3 points for each 50% increase in relative abundance of 13 proteins predominantly involved in inflammation. Among them, IGFBP-acid labile subunit, orosomucoid 1 (ORM1), Apo C-I, and pyruvate kinase isoenzymes M1/M2 jointly explained 37% of the variance in UNIT scores. After additional adjustment for height-for-age Z-score and household socio-economic status as indicators of long-term nutritional and social stress, associations with 6 proteins involved in inflammation, including ORM1, α-1-antichymotrypsin, reticulocalbin 1, and 3 components of the complement cascade, remained significant (q<0.05). Using untargeted proteomics, stable, constitutive facets of subclinical inflammation were associated with lower developmental test performance in this rural South Asian child population. Plasma proteomics may offer opportunities to identify functional, antecedent biomarkers of child cognitive development." @default.
• W2316397705 created "2016-06-24" @default.
• W2316397705 creator A5015933395 @default.
• W2316397705 creator A5041086386 @default.
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• W2316397705 creator A5071551351 @default.
• W2316397705 creator A5078418860 @default.
• W2316397705 creator A5081154671 @default.
• W2316397705 creator A5089963590 @default.
• W2316397705 date "2016-08-01" @default.
• W2316397705 modified "2023-09-29" @default.
• W2316397705 title "General intelligence is associated with subclinical inflammation in Nepalese children: A population-based plasma proteomics study" @default.
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• W2316397705 doi "https://doi.org/10.1016/j.bbi.2016.03.023" @default.
• W2316397705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4929134" @default.
• W2316397705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27039242" @default.
• W2316397705 hasPublicationYear "2016" @default.

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